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Possible impact of dopamine SPECT on decision-making for drug treatment in Parkinsonian syndrome

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Summary.

Single-photon emission computed tomography (SPECT) markers allow measuring the integrity of the brain dopaminergic system in vivo. We used dopamine transporter (DAT) SPECT with [123I]FP-CIT and dopamine D2/D3 receptor SPECT with [123I]IBZM to evaluate whether there is a reduction of DAT and/or D2/D3 receptor SPECT in treated and untreated patients with Parkinsonian syndrome (PS). We found that almost a quarter of our patients treated with anti-Parkinsonian medication prior to SPECT imaging did not show evidence of a presynaptic dopaminergic deficit while 37% of untreated patients were diagnosed as having Parkinson’s disease. 17% of treated patients had additional loss of D2/D3 receptor binding capacity in concordance with the clinical follow-up diagnoses of multiple system atrophy, progressive nuclear palsy, and vascular Parkinsonism. Apart from 38% clinically uncertain cases, SPECT was in concordance with 75% of initial clinical diagnoses. 25% were reclassified as indicated by SPECT findings and confirmed by a 1.5-year clinical follow-up. We conclude that dopamine SPECT may support establishing or refuting the clinical diagnosis and, therefore, help to make the decision for or against dopaminomimetic treatment in cases with PS.

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References

  • S Asenbaum W Pirker P Angelberger G Bencsits M Pruckmayer T Brücke (1998) ArticleTitle[123I]β-CIT and SPECT in essential tremor and Parkinson’s disease J Neural Transm 105 1213–1228 Occurrence Handle9928890 Occurrence Handle1:CAS:528:DyaK1MXhslGms7g%3D Occurrence Handle10.1007/s007020050124

    Article  PubMed  CAS  Google Scholar 

  • H Barthel U Müller T Wächter P Slomka C Dannenberg T Murai et al. (2000) ArticleTitle[Multimodal SPECT and MRT imaging data analysis for an improvement in the diagnosis of idiopathic Parkinson’s syndrome] Radiologe 40 863–869 Occurrence Handle11103409 Occurrence Handle1:STN:280:DC%2BD3M%2FmvVWgsA%3D%3D Occurrence Handle10.1007/s001170050845

    Article  PubMed  CAS  Google Scholar 

  • HT Benamer WH Oertel J Patterson DM Hadley O Pogarell H Höffken et al. (2003) ArticleTitleProspective study of presynaptic dopaminergic imaging in patients with mild parkinsonism and tremor disorders, part 1. Baseline and 3-month observations Mov Disord 18 977–984 Occurrence Handle14502664 Occurrence Handle10.1002/mds.10482

    Article  PubMed  Google Scholar 

  • HT Benamer J Patterson DJ Wyper DM Hadley GJ Macphee DG Grosset (2000) ArticleTitleCorrelation of Parkinson’s disease severity and duration with 123I-FP-CIT SPECT striatal uptake Mov Disord 15 692–698 Occurrence Handle10928580 Occurrence Handle1:STN:280:DC%2BD3M%2FotlWqsg%3D%3D Occurrence Handle10.1002/1531-8257(200007)15:4<692::AID-MDS1014>3.0.CO;2-V

    Article  PubMed  CAS  Google Scholar 

  • TS Benamer J Patterson DG Grosset J Booij K de Bruin E van Royen et al. (2000) ArticleTitleAccurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group Mov Disord 15 503–510 Occurrence Handle10830416 Occurrence Handle1:STN:280:DC%2BD3cvnsVSntw%3D%3D Occurrence Handle10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V

    Article  PubMed  CAS  Google Scholar 

  • J Booij JB Habraken P Bergmans G Tissingh A Winogrodzka EC Wolters et al. (1998) ArticleTitleImaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson’s disease J Nucl Med 39 1879–1884 Occurrence Handle9829575 Occurrence Handle1:CAS:528:DyaK1cXnsFWjsLY%3D

    PubMed  CAS  Google Scholar 

  • Brücke T, Djamshidian S, Bencsits G, Pirker W, Asenbaum S, Podreka I (2000) SPECT and PET imaging of the dopaminergic system in Parkinson’s disease. J Neurol 247 [Suppl 4]: IV/2–7

  • AM Catafau E Tolosa (2004) ArticleTitleImpact of dopamine transporter SPECT using 123I-Ioflupane on diagnosis and management of patients with clinically uncertain parkinsonian syndromes Mov Disord 19 1175–1182 Occurrence Handle15390019 Occurrence Handle10.1002/mds.20112

    Article  PubMed  Google Scholar 

  • RC Dodel H Höffken JC Möller B Bornschein T Klockgether T Behr WH Oertel U Siebert (2003) ArticleTitleDopamine transporter imaging and SPECT in diagnostic work-up of Parkinson’s disease: a decision-analytic approach Mov Disord 18 IssueIDSuppl 7 S52–S62 Occurrence Handle14531047 Occurrence Handle10.1002/mds.10580

    Article  PubMed  Google Scholar 

  • T Eckert M Sailer J Kaufmann C Schrader T Peschel N Bodammer et al. (2004) ArticleTitleDifferentiation of idiopathic Parkinson’s disease, multiple system atrophy, progressive supranuclear palsy, and healthy controls using magnetization transfer imaging NeuroImage 21 229–235 Occurrence Handle14741660 Occurrence Handle10.1016/j.neuroimage.2003.08.028

    Article  PubMed  Google Scholar 

  • S Fahn (1999) ArticleTitleParkinson disease, the effect of levodopa, and the ELLDOPA trial. Earlier vs Later L-DOPA Arch Neurol 56 529–535 Occurrence Handle10328247 Occurrence Handle1:STN:280:DyaK1M3lvVOquw%3D%3D Occurrence Handle10.1001/archneur.56.5.529

    Article  PubMed  CAS  Google Scholar 

  • JM Fearnley AJ Lees (1991) ArticleTitleAgeing and Parkinson’s disease: substantia nigra regional selectivity Brain 114 2283–2301 Occurrence Handle1933245

    PubMed  Google Scholar 

  • T Gasser J Schwarz G Arnold C Trenkwalder WH Oertel (1992) ArticleTitleApomorphine test for dopaminergic responsiveness in patients with previously untreated Parkinson’s disease Arch Neurol 49 1131–1134 Occurrence Handle1444878 Occurrence Handle1:STN:280:ByyD2svltFA%3D

    PubMed  CAS  Google Scholar 

  • W Gerschlager G Bencsits W Pirker BR Bloem S Asenbaum D Prayer et al. (2002) ArticleTitle[123I]β-CIT SPECT distinguishes vascular parkinsonism from Parkinson’s disease Mov Disord 17 518–523 Occurrence Handle12112200 Occurrence Handle10.1002/mds.10092

    Article  PubMed  Google Scholar 

  • S Gilman PA Low N Quinn A Albanese Y Ben-Shlomo CJ Flower et al. (1998) ArticleTitleConsensus statement on the diagnosis of multiple system atrophy J Neurol Sci 163 94–98 Occurrence Handle10.1016/S0022-510X(98)00304-9

    Article  Google Scholar 

  • Grosset D (2004) General Electric Healthcare Symposium. Annual Congress, European Association of Nuclear Medicine, September 4–8, 2004, Helsinki, Finland; www.datscan.com

  • A Hermann M Gerlach J Schwarz A Storch (2004) ArticleTitleNeurorestoration in Parkinson’s disease by cell replacement and endogenous regeneration Expert Opin Biol Ther 4 131–143 Occurrence Handle14998773 Occurrence Handle10.1517/14712598.4.2.131

    Article  PubMed  Google Scholar 

  • S Hesse H Barthel W Hermann T Murai R Kluge A Wagner et al. (2003) ArticleTitleRegional serotonin transporter availability and depression are correlated in Wilson’s disease J Neural Transm 110 923–933 Occurrence Handle12898347 Occurrence Handle1:CAS:528:DC%2BD3sXlvVWqurY%3D Occurrence Handle10.1007/s00702-003-0008-8

    Article  PubMed  CAS  Google Scholar 

  • J Hierholzer M Cordes S Venz L Schelosky C Harisch W Richter et al. (1998) ArticleTitleLoss of dopamine-D2 receptor binding sites in Parkinsonian plus syndromes J Nucl Med 39 954–960 Occurrence Handle9627325 Occurrence Handle1:CAS:528:DyaK1cXktV2itr0%3D

    PubMed  CAS  Google Scholar 

  • RG Holloway I Shoulson S Fahn K Kieburtz A Lang K Marek et al. (2004) ArticleTitlePramipexole vs levodopa as initial treatment for Parkinson disease: a 4-year randomized controlled trial Arch Neurol 61 1044–1053 Occurrence Handle15262734 Occurrence Handle10.1001/archneur.61.7.1044

    Article  PubMed  Google Scholar 

  • MT Hu SJ White AH Herlihy KR Chaudhuri JV Hajnal DJ Brooks (2001) ArticleTitleA comparison of 18F-dopa PET and inversion recovery MRI in the diagnosis of Parkinson’s disease Neurology 56 1195–1200 Occurrence Handle11342685 Occurrence Handle1:STN:280:DC%2BD3MzntFanuw%3D%3D

    PubMed  CAS  Google Scholar 

  • AJ Hughes SE Daniel L Kilford AJ Lees (1993) ArticleTitleAccuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases J Neurol Neurosurg Psychiatry 55 181–184 Occurrence Handle10.1136/jnnp.55.3.181

    Article  Google Scholar 

  • AJ Hughes SE Daniel AJ Lees (2001) ArticleTitleImproved accuracy of clinical diagnosis of Lewy body Parkinson’s disease Neurology 57 1497–1499 Occurrence Handle11673599 Occurrence Handle1:STN:280:DC%2BD3MrmslCltA%3D%3D

    PubMed  CAS  Google Scholar 

  • WJ Hwang WJ Yao SP Wey LH Shen G Ting (2002) ArticleTitleDown regulation of striatal dopamine D2 receptors in advanced Parkinson’s disease contributes to the development of motor fluctuation Eur Neurol 47 113–117 Occurrence Handle11844900 Occurrence Handle1:CAS:528:DC%2BD38XhtFOru78%3D Occurrence Handle10.1159/000047962

    Article  PubMed  CAS  Google Scholar 

  • J Jankovic AH Rajput MP McDermott DP Perl (2000) ArticleTitleThe evolution of diagnosis in early Parkinson disease. Parkinson Study Group Arch Neurol 3 369–372 Occurrence Handle10.1001/archneur.57.3.369

    Article  Google Scholar 

  • DL Jennings JP Seibyl D Oakes S Eberly J Murphy K Marek (2004) ArticleTitle 123I-β-CIT and single-photon emission computed tomographic imaging vs clinical evaluation in Parkinsonian syndrome: unmasking an early diagnosis Arch Neurol 61 1224–1229 Occurrence Handle15313838 Occurrence Handle10.1001/archneur.61.8.1224

    Article  PubMed  Google Scholar 

  • B Jeon JM Kim JM Jeong KM Kim YS Chang DS Lee et al. (1998) ArticleTitleDopamine transporter density measured by [123I]β-CIT single-photon emission computed tomography is normal in dopa-responsive dystonia Ann Neurol 43 792–800 Occurrence Handle9629849 Occurrence Handle1:CAS:528:DyaK1cXktVSjs7c%3D Occurrence Handle10.1002/ana.410430614

    Article  PubMed  CAS  Google Scholar 

  • R Juh J Kim D Moon B Choe T Suh (2004) ArticleTitleDifferent metabolic patterns analysis of Parkinsonism on the 18F-FDG PET Eur J Radiol 51 223–233 Occurrence Handle15294329 Occurrence Handle10.1016/S0720-048X(03)00214-6

    Article  PubMed  Google Scholar 

  • YJ Kim M Ichise JR Ballinger D Vines SS Erami T Tatschida et al. (2002) ArticleTitleCombination of dopamine transporter and D2 receptor SPECT in the diagnostic evaluation of PD, MSA, and PSP Mov Disord 17 303–312 Occurrence Handle11921116 Occurrence Handle10.1002/mds.10042

    Article  PubMed  Google Scholar 

  • GM Knudsen M Karlsborg G Thomsen K Krabbe L Regeur T Nygaard et al. (2004) ArticleTitleImaging of dopamine transporters and D2 receptors in patients with Parkinson’s disease and multiple system atrophy Eur J Nucl Med Mol Imaging 31 1631–1638 Occurrence Handle15583914 Occurrence Handle1:CAS:528:DC%2BD2cXhtVCmurrN Occurrence Handle10.1007/s00259-004-1578-x

    Article  PubMed  CAS  Google Scholar 

  • J Lavalaye J Booij L Reneman JB Habraken EA van Royen (2000) ArticleTitleEffect of age and gender on dopamine transporter imaging with [123I] FP-CIT SPET in healthy volunteers Eur J Nucl Med 27 867–869 Occurrence Handle10952500 Occurrence Handle1:CAS:528:DC%2BD3cXktVOjsb0%3D Occurrence Handle10.1007/s002590000279

    Article  PubMed  CAS  Google Scholar 

  • I Litvan Y Agid D Calne G Campbell B Dubois RC Duvoisin et al. (1996) ArticleTitleClinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewskisyndrome): report of the NINDS-SPSP International Workshop Neurology 47 1–9 Occurrence Handle8710059 Occurrence Handle1:STN:280:BymB1M7gtVI%3D

    PubMed  CAS  Google Scholar 

  • K Marek D Jennings J Seibyl (2003) ArticleTitleImaging the dopamine system to assess disease-modifying drugs: studies comparing dopamine agonists and levodopa Neurology 61 IssueID[Suppl 3] S43–S48 Occurrence Handle14504379 Occurrence Handle1:CAS:528:DC%2BD3sXot1Ggtr0%3D

    PubMed  CAS  Google Scholar 

  • KL Marek JP Seibyl SS Zoghbi Y Zea-Ponce RM Baldwin B Fussell et al. (1996) ArticleTitle[123I]β-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson’s disease Neurology 46 231–237 Occurrence Handle8559382 Occurrence Handle1:STN:280:BymC2czhvFA%3D

    PubMed  CAS  Google Scholar 

  • V Marshall DG Grosset (2003) ArticleTitleRole of dopamine transporter imaging in the diagnosis of atypical tremor disorders Mov Disord 18 IssueID[Suppl 7] S22–S27 Occurrence Handle14531042 Occurrence Handle10.1002/mds.10574

    Article  PubMed  Google Scholar 

  • V Marshall DG Grosset (2005) ArticleTitleReply: The meaning of negative DAT and F-Dopa PET scans in a patient with clinical Parkinson’s disease Mov Disord 20 118 Occurrence Handle10.1002/mds.20313

    Article  Google Scholar 

  • J Meara BK Bhowmick P Hobson (1999) ArticleTitleAccuracy of diagnosis in patients with presumed Parkinson’s disease Age Ageing 28 99–102 Occurrence Handle10350403 Occurrence Handle1:STN:280:DyaK1M3nsl2jtA%3D%3D Occurrence Handle10.1093/ageing/28.2.99

    Article  PubMed  CAS  Google Scholar 

  • PT Meyer B Sattler T Lincke A Seese O Sabri (2003) ArticleTitleInvestigating dopaminergic neurotransmission with 123I-FP-CIT SPECT: comparability of modern SPECT systems J Nucl Med 44 839–845 Occurrence Handle12732687 Occurrence Handle1:CAS:528:DC%2BD3sXkt1Kitrw%3D

    PubMed  CAS  Google Scholar 

  • PD Mozley JS Schneider PD Acton K Plössl MB Stern A Siderowf et al. (2000) ArticleTitleBinding of [99mTc]TRODAT-1 to dopamine transporters in patients with Parkinson’s disease and in healthy volunteers J Nucl Med 41 584–589 Occurrence Handle10768556 Occurrence Handle1:CAS:528:DC%2BD3cXivF2hu70%3D

    PubMed  CAS  Google Scholar 

  • A Müller H Reichmann A Livermore T Hummel (2002) ArticleTitleOlfactory function in idiopathic Parkinson’s disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients J Neural Transm 109 805–811 Occurrence Handle12111470 Occurrence Handle10.1007/s007020200013

    Article  PubMed  Google Scholar 

  • H Oba A Yagishita H Terada AJ Barkovich K Kutomi T Yamauchi et al. (2005) ArticleTitleNew and reliable MRI diagnosis for progressive supranuclear palsy Neurology 64 2050–2055 Occurrence Handle15985570 Occurrence Handle1:STN:280:DC%2BD2MzjsFSgtw%3D%3D Occurrence Handle10.1212/01.WNL.0000165960.04422.D0

    Article  PubMed  CAS  Google Scholar 

  • P Piccini A Whone (2004) ArticleTitleFunctional brain imaging in the differential diagnosis of Parkinson’s disease Lancet Neurol 3 284–290 Occurrence Handle15099543 Occurrence Handle10.1016/S1474-4422(04)00736-7

    Article  PubMed  Google Scholar 

  • M Plotkin H Amthauer S Klaffke A Kuhn L Ludemann G Arnold KD Wernecke A Kupsch R Felix S Venz (2005a) ArticleTitleCombined 123I-FP-CIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients J Neural Transm 112 677–692 Occurrence Handle1:STN:280:DC%2BD2M7ps1SnsA%3D%3D Occurrence Handle10.1007/s00702-004-0208-x

    Article  CAS  Google Scholar 

  • M Plotkin H Amthauer S Quill F Marzinzik F Klostermann S Klaffke et al. (2005b) ArticleTitleImaging of dopamine transporters and D2 receptors in vascular parkinsonism: a report of four cases J Neural Transm 112 1355–1361 Occurrence Handle1:STN:280:DC%2BD2MrhtFWhuw%3D%3D Occurrence Handle10.1007/s00702-005-0278-4

    Article  CAS  Google Scholar 

  • A Rajput CA Robinson AH Rajput (2004) ArticleTitleEssential tremor course and disability: a clinicopathologic study of 20 cases Neurology 62 932–936 Occurrence Handle15037695

    PubMed  Google Scholar 

  • B Ravina D Eidelberg JE Ahlskog RL Albin DJ Brooks M Carbon et al. (2005) ArticleTitleThe role of radiotracer imaging in Parkinson disease Neurology 64 208–215 Occurrence Handle15668415 Occurrence Handle1:STN:280:DC%2BD2M%2FktFSnsA%3D%3D

    PubMed  CAS  Google Scholar 

  • Riederer P, Gille G, Müller T, Przuntek H, Reichmann H, Riess O, Schwartz A, Schwarz J, Vogt T (2002) Practical importance of neuroprotection in Parkinson’s disease. J Neurol 249 [Suppl 3]: III/53 56

  • J Schwarz E Kraft T Vogl G Arnold K Tatsch WH Oertel (1999) ArticleTitleRelative quantification of signal on T2-weighted images in the basal ganglia: limited value in differential diagnosis of patients with parkinsonism Neuroradiology 41 124–128 Occurrence Handle10090605 Occurrence Handle1:STN:280:DyaK1M7ovFSitg%3D%3D Occurrence Handle10.1007/s002340050716

    Article  PubMed  CAS  Google Scholar 

  • J Schwarz R Linke M Kerner PD Mozley C Trenkwalder T Gasser K Tatsch (2000) ArticleTitleStriatal dopamine transporter binding assessed by [I-123]IPT and single photon emission computed tomography in patients with early Parkinson’s disease: implications for a preclinical diagnosis Arch Neurol 57 205–258 Occurrence Handle10681078 Occurrence Handle1:STN:280:DC%2BD3c7ktleisQ%3D%3D Occurrence Handle10.1001/archneur.57.2.205

    Article  PubMed  CAS  Google Scholar 

  • J Schwarz WH Oertel K Tatsch (1996) ArticleTitleIodine-123-iodobenzamide binding in parkinsonism: reduction by dopamine agonists but not L-Dopa J Nucl Med 37 1112–1115 Occurrence Handle8965179 Occurrence Handle1:CAS:528:DyaK28XksF2iur8%3D

    PubMed  CAS  Google Scholar 

  • J Schwarz A Storch W Koch O Pogarell PE Radau K Tatsch (2004) ArticleTitleLoss of dopamine transporter binding in Parkinson’s disease follows a single exponential rather than a linear decline J Nucl Med 45 1694–1697 Occurrence Handle15471835 Occurrence Handle1:CAS:528:DC%2BD2cXpslCqs70%3D

    PubMed  CAS  Google Scholar 

  • J Schwarz K Tatsch T Gasser G Arnold O Pogarell G Kunig WH Oertel (1997) ArticleTitle[123]IBZM binding predicts dopaminergic responsiveness in patients with parkinsonism and previous dopaminomimetic therapy Mov Disord 12 898–902 Occurrence Handle9399212 Occurrence Handle1:STN:280:DyaK1c%2FmtFKisg%3D%3D Occurrence Handle10.1002/mds.870120610

    Article  PubMed  CAS  Google Scholar 

  • JP Seibyl K Marek K Sheff S Zoghbi RM Baldwin DS Charney CH van Dyck RB Innis (1998) ArticleTitleIodine-123-β-CIT and iodine-123-FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson’s patients J Nucl Med 39 1500–1508 Occurrence Handle9744331 Occurrence Handle1:CAS:528:DyaK1cXmtlyiu7k%3D

    PubMed  CAS  Google Scholar 

  • K Seppi MF Schocke R Esterhammer C Kremser C Brenneis J Mueller S Boesch W Jaschke W Poewe GK Wenning (2003) ArticleTitleDiffusion-weighted imaging discriminates progressive supranuclear palsy from PD, but not from the parkinson variant of multiple system atrophy Neurology 60 922–927 Occurrence Handle12654954 Occurrence Handle1:STN:280:DC%2BD3s7ktVWnuw%3D%3D

    PubMed  CAS  Google Scholar 

  • K Seppi MF Schocke E Donnemiller R Esterhammer C Kremser C Scherfler A Diem W Jaschke GK Wenning W Poewe (2004) ArticleTitleComparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson’s disease Mov Disord 19 1438–1445 Occurrence Handle15390073 Occurrence Handle10.1002/mds.20229

    Article  PubMed  Google Scholar 

  • Seppi K, Schocke MF, Wenning GK, Poewe W (2005) How to diagnose MSA early: round table magnetic resonance imaging. J Neural Transm 112 (in press)

  • K Tatsch (2002) ArticleTitleCan SPET imaging of dopamine uptake sites replace PET imaging in Parkinson’s disease? For Eur J Nucl Med Mol Imaging 29 711–714 Occurrence Handle10.1007/s00259-002-0814-5 Occurrence Handle1:CAS:528:DC%2BD38XkvFSnsL8%3D

    Article  CAS  Google Scholar 

  • G Tissingh P Bergmans J Booij A Winogrodzka EA van Royen JC Stoof EC Wolters (1998) ArticleTitleDrug-naive patients with Parkinson’s disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]β-CIT SPECT J Neurol 245 14–20 Occurrence Handle9457623 Occurrence Handle1:STN:280:DyaK1c7hvV2ltQ%3D%3D Occurrence Handle10.1007/s004150050168

    Article  PubMed  CAS  Google Scholar 

  • E Tolosa M Coelho M Gallardo (2003) ArticleTitleDAT imaging in drug-induced and psychogenic parkinsonism Mov Disord 18 IssueID[Suppl 7] S28–S33 Occurrence Handle14531043 Occurrence Handle10.1002/mds.10575

    Article  PubMed  Google Scholar 

  • T Vander Borght E Tolosa InstitutionalAuthorNameon behalf of DaTSCAN CUPS Study Group (2004) ArticleTitleAssessment of 123I-ioflupane (DaTSCAN™) diagnostic accuracy by a two year follow-up study of patients with clinically uncertain parkinsonism Eur J Nucl Med Mol Imaging 31 IssueID[Suppl 2] S247

    Google Scholar 

  • CH van Dyck JP Seibyl RT Malison M Laruelle SS Zoghbi RM Baldwin RB Innis (2002) ArticleTitleAge-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries Am J Geriatr Psychiatry 10 36–43 Occurrence Handle11790633 Occurrence Handle10.1176/appi.ajgp.10.1.36

    Article  PubMed  Google Scholar 

  • K van Laere P Santens T Bosman J de Reuck L Mortelmans R Dierckx (2004) ArticleTitleStatistical parametric mapping of 99mTc-ECD SPECT in idiopathic Parkinson’s disease and multiple system atrophy with predominant parkinsonian features: correlation with clinical parameters J Nucl Med 45 933–942 Occurrence Handle15181127

    PubMed  Google Scholar 

  • A Varrone KL Marek D Jennings RB Innis JP Seibyl (2001) ArticleTitle[123I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson’s disease and multiple system atrophy Mov Disord 16 1023–1032 Occurrence Handle11748733 Occurrence Handle1:STN:280:DC%2BD3MnpvFCisA%3D%3D Occurrence Handle10.1002/mds.1256

    Article  PubMed  CAS  Google Scholar 

  • A Varrone MT Pellecchia M Amboni V Sansone E Salvatore D Ghezzi et al. (2004) ArticleTitleImaging of dopaminergic dysfunction with [123I] FP-CIT SPECT in early-onset parkin disease Neurology 63 2097–2103 Occurrence Handle15596756 Occurrence Handle1:STN:280:DC%2BD2cnitFOjtw%3D%3D

    PubMed  CAS  Google Scholar 

  • U Walter C Klein R Hilker R Benecke PP Pramstaller D Dressler (2004) ArticleTitleBrain parenchyma sonography detects preclinical parkinsonism Mov Disord 19 1445–1449 Occurrence Handle15390070 Occurrence Handle10.1002/mds.20232

    Article  PubMed  Google Scholar 

  • U Walter L Niehaus T Probst R Benecke BU Meyer D Dressler (2003) ArticleTitleBrain parenchyma sonography discriminates Parkinson’s disease and atypical parkinsonian syndromes Neurology 60 74–77 Occurrence Handle12525721 Occurrence Handle1:CAS:528:DC%2BD3sXmvFGqsr4%3D Occurrence Handle10.1159/000071230

    Article  PubMed  CAS  Google Scholar 

  • AL Whone RL Watts AJ Stoessl M Davis S Reske C Nahmias et al. (2003) ArticleTitleSlower progression of Parkinson’s disease with ropinirole versus levodopa: the REAL-PET study Ann Neurol 54 93–101 Occurrence Handle12838524 Occurrence Handle1:CAS:528:DC%2BD3sXlvVWisrw%3D Occurrence Handle10.1002/ana.10609

    Article  PubMed  CAS  Google Scholar 

  • J Winikates J Jankovic (1999) ArticleTitleClinical correlates of vascular parkinsonism Arch Neurol 56 98–102 Occurrence Handle9923767 Occurrence Handle1:STN:280:DyaK1M7itVKnsA%3D%3D Occurrence Handle10.1001/archneur.56.1.98

    Article  PubMed  CAS  Google Scholar 

  • A Winogrodzka J Booij ECh Wolters (2005) ArticleTitleDisease-related and drug-induced changes in dopamine transporter expression might undermine the reliability of imaging studies of disease progression in Parkinson’s disease Parkinsonism Relat Disord 11 475–484 Occurrence Handle16257254 Occurrence Handle1:STN:280:DC%2BD2MnhsFKisA%3D%3D

    PubMed  CAS  Google Scholar 

  • F Yekhlef G Ballan F Macia O Delmer C Sourgen F Tison (2003) ArticleTitleRoutine MRI for differential diagnosis of Parkinson’s disease, MSA, PSP, CBD J Neural Transm 110 151–169 Occurrence Handle12589575 Occurrence Handle1:STN:280:DC%2BD3s%2FnvVWktg%3D%3D Occurrence Handle10.1007/s00702-002-0785-5

    Article  PubMed  CAS  Google Scholar 

  • JC Zijlmans R Katzenschlager SE Daniel AJ Lees (2004) ArticleTitleThe L-dopa response in vascular parkinsonism J Neurol Neurosurg Psychiatry 75 545–547 Occurrence Handle15026493 Occurrence Handle1:STN:280:DC%2BD2c7lvFWnsQ%3D%3D Occurrence Handle10.1136/jnnp.2003.018309

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Clinic for Nuclear Medicine, University Hospital, Leipzig, Germany

    S. Hesse, H. Barthel, D. Polster & O. Sabri

  2. Specialized Outpatient’s Centre for Parkinson’s Disease, Gera, Germany

    C. Oehlwein

  3. Clinic for Neurology, University Hospital, Leipzig, Germany

    J. Schwarz & A. Wagner

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  1. S. Hesse
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  2. C. Oehlwein
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  3. H. Barthel
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  4. J. Schwarz
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  5. D. Polster
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  6. A. Wagner
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  7. O. Sabri
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Hesse, S., Oehlwein, C., Barthel, H. et al. Possible impact of dopamine SPECT on decision-making for drug treatment in Parkinsonian syndrome. J Neural Transm 113, 1177–1190 (2006). https://doi.org/10.1007/s00702-005-0401-6

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