Skip to main content

Advertisement

Log in

Striatal FP-CIT uptake differs in the subtypes of early Parkinson’s disease

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

In idiopathic Parkinson’s disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I-123]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p<0.01). Contralateral putamen and caudate nucleus FP-CIT uptake correlated significantly with severity of rigidity (p<0.01) and hypokinesia (p<0.01) but not with severity of resting or postural tremor (p>0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • S Asenbaum W Pirker P Angelberger G Bencsits M Pruckmayer T Brücke (1998) ArticleTitle[123I]β-CIT SPECT in essential tremor and Parkinson’s disease J Neural Transm 105 1213–1228 Occurrence Handle9928890 Occurrence Handle10.1007/s007020050124 Occurrence Handle1:CAS:528:DyaK1MXhslGms7g%3D

    Article  PubMed  CAS  Google Scholar 

  • HTS Benamer J Patterson DG Grosset (2000a) ArticleTitleAccurate differentiation of parkinsonian and essential tremor using visual assessment of [123I]-FP-CIT-SPECT imaging: the [123I]-FP-CIT study group Mov Disord 15 503–510 Occurrence Handle10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V Occurrence Handle1:STN:280:DC%2BD3cvnsVSntw%3D%3D

    Article  CAS  Google Scholar 

  • HTS Benamer J Patterson DJ Wyper DM Hadley GJA MacPhee DG Grosset (2000b) ArticleTitleCorrelation of Parkinson’s disease severity and duration with 123I-FP-CIT SPECT striatal uptake Mov Disord 15 692–698 Occurrence Handle10.1002/1531-8257(200007)15:4<692::AID-MDS1014>3.0.CO;2-V Occurrence Handle1:STN:280:DC%2BD3M%2FotlWqsg%3D%3D

    Article  CAS  Google Scholar 

  • HTS Benamer WH Oertel J Patterson DM Hadley O Pogareff H Hoffken A Gerstner DG Grosset (2003) ArticleTitleProspective study of presynaptic dopaminergic imaging in patients with mild parkinsonism and tremor disorders: Part 1. baseline and 3-month observations Mov Disord 18 977–984 Occurrence Handle14502664 Occurrence Handle10.1002/mds.10482

    Article  PubMed  Google Scholar 

  • J Booij EB Sokole MG Stabin AGM Janssen K de Bruin EA van Royen (1998) ArticleTitleHuman biodistribution and dosimetry of [123I]FP-CIT: a potential radioligand for imaging of dopamine transporters Eur J Nucl Med 25 24–30 Occurrence Handle9396871 Occurrence Handle10.1007/s002590050190 Occurrence Handle1:CAS:528:DyaK2sXnvVGru78%3D

    Article  PubMed  CAS  Google Scholar 

  • S Fahn RL Elton InstitutionalAuthorNameand members of the UPDRS Development Committee (1987) Unified Parkinson’s disease rating scale S Fahn CD Marsden DB Calne M Goldstein (Eds) Recent developments in Parkinson’s disease Macmillan Healthcare Information Florham Park, HJ 153–164

    Google Scholar 

  • MM Hoehn MD Yahr (1967) ArticleTitleParkinsonism: onset, progression and mortality Neurology 17 427–442 Occurrence Handle6067254 Occurrence Handle1:STN:280:CCiC3sbgtlQ%3D Occurrence Handle10.1159/000137111

    Article  PubMed  CAS  Google Scholar 

  • A Hughes SE Daniel L Kilford AJ Lees (1992) ArticleTitleAccuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases J Neurol Neurosurg Psychiatry 55 181–184 Occurrence Handle1564476 Occurrence Handle1:STN:280:By2B38nnsFQ%3D Occurrence Handle10.1136/jnnp.55.3.181

    Article  PubMed  CAS  Google Scholar 

  • M Ichise YJ Kim JR Ballinger D Vines SS Erami F Tanaka AE Lang (1999) ArticleTitleSPECT imaging of pre- and postsynaptic dopaminergic alterations in L-dopa untreated Parkinson’s disease Neurology 52 1206–1214 Occurrence Handle10214745 Occurrence Handle1:CAS:528:DyaK1MXivVyqt7Y%3D

    PubMed  CAS  Google Scholar 

  • YJ Kim M Ichise JR Ballinger D Vines SS Erami T Tatschida AE Lang (2002) ArticleTitleCombination of dopamine transporter and D2 receptor SPECT in the diagnostic evaluation of PD, MSA and PSP Mov Disord 17 303–312 Occurrence Handle11921116 Occurrence Handle10.1002/mds.10042

    Article  PubMed  Google Scholar 

  • A Korchounov HI Schipper IS Preobrazhenskaya KR Kessler NN Yakhno (2004) ArticleTitleDifferences in age at onset and familial aggregation between clinical types of idiopathic Parkinson’s disease Mov Disord 19 1059–1064 Occurrence Handle15372596 Occurrence Handle10.1002/mds.20061

    Article  PubMed  Google Scholar 

  • M Laruelle RM Baldwin RT Malison Y Zea-Ponce SS Zogbhi MS Al-Tikriti EH Sybirska RC Zimmermann G Wisniewski JL Neumeyer (1993) ArticleTitleSPECT imaging of dopamine and serotonin transporters with [123I]ß-CIT: pharmacological characterization of brain uptake in non-human primates Synapse 13 295–309 Occurrence Handle7683143 Occurrence Handle10.1002/syn.890130402 Occurrence Handle1:CAS:528:DyaK3sXksVWisL4%3D

    Article  PubMed  CAS  Google Scholar 

  • SJG Lewis T Foltynie AD Blackwell TW Robbins AM Owen RA Barker (2005) ArticleTitleHeterogeneity of Parkinson’s disease in the early clinical stages using a data driven approach J Neurol Neurosurg Psychiatry 76 343–348 Occurrence Handle15716523 Occurrence Handle10.1136/jnnp.2003.033530 Occurrence Handle1:STN:280:DC%2BD2M7htFOrsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • M Otsuka Y Ichiya Y Kuwabara S Hosokawa M Sasaki T Yoshida T Fukumura K Masuda M Kato (1996) ArticleTitleDifferences in the reduced 18F-Dopa uptakes of the caudate and the putamen in Parkinson’s disease: correlations with the three main symptoms J Neurol Sci 136 169–173 Occurrence Handle8815166 Occurrence Handle10.1016/0022-510X(95)00316-T Occurrence Handle1:CAS:528:DyaK28XisFymsbs%3D

    Article  PubMed  CAS  Google Scholar 

  • W Pirker S Asenbaum G Bencsits D Prayer W Gerschlager L Deecke T Brucke (2000) ArticleTitle[123I]beta-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration Mov Disord 15 1158–1167 Occurrence Handle11104200 Occurrence Handle10.1002/1531-8257(200011)15:6<1158::AID-MDS1015>3.0.CO;2-0 Occurrence Handle1:STN:280:DC%2BD3MzgsVahsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • W Pirker (2003) ArticleTitleCorrelation of dopamine transporter imaging with parkinsonian motor handicap: how close is it? Mov Disord 18 IssueIDSuppl 7 S43–S51 Occurrence Handle14531046 Occurrence Handle10.1002/mds.10579

    Article  PubMed  Google Scholar 

  • JO Rinne H Ruottinen J Bergman M Haaparanta P Sonninen O Solin (1999) ArticleTitleUsefulness of a dopamine transporter PET ligand [(18)F]beta-CFT in assessing disability in Parkinson’s disease J Neurol Neurosurg Psychiatry 67 737–741 Occurrence Handle10567489 Occurrence Handle1:STN:280:DC%2BD3c%2Fjs1Ohsw%3D%3D Occurrence Handle10.1136/jnnp.67.6.737

    Article  PubMed  CAS  Google Scholar 

  • JP Seibyl KL Marek D Quinlan K Sheff S Zoghbi Y Zea-Ponce RM Baldwin B Fussell EO Smith DS Charney (1995) ArticleTitleDecreased single photon emission computed tomography [123I]ß-CIT striatal uptake correlates with symptom severity in Parkinson’s disease Ann Neurol 38 589–598 Occurrence Handle7574455 Occurrence Handle10.1002/ana.410380407 Occurrence Handle1:STN:280:BymD3c7itFE%3D

    Article  PubMed  CAS  Google Scholar 

  • J Spiegel MO Mollers WH Jost G Fuss S Samnick U Dillmann G Becker CM Kirsch (2005) ArticleTitleFP-CIT and MIBG scintigraphy in early Parkinson’s disease Mov Disord 20 552–561 Occurrence Handle15645531 Occurrence Handle10.1002/mds.20369

    Article  PubMed  Google Scholar 

  • FJ Vingerhoets M Schulzer DB Calne BJ Snow (1997) ArticleTitleWhich clinical sign of Parkinson’s disease best reflects the nigrostriatal lesion? Ann Neurol 41 58–64 Occurrence Handle9005866 Occurrence Handle10.1002/ana.410410111 Occurrence Handle1:STN:280:ByiC2MfltVI%3D

    Article  PubMed  CAS  Google Scholar 

  • A Winogrodzka P Bergmans J Booij EA van Royen AGM Janssen EC Wolters (2001) ArticleTitle[123I]FP-CIT SPECT is a useful method to monitor the rate of dopaminergic degeneration in early-stage Parkinson’s disease J Neural Transm 108 1011–1019 Occurrence Handle11716136 Occurrence Handle10.1007/s007020170019 Occurrence Handle1:CAS:528:DC%2BD3MXotlGjs7s%3D

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spiegel, J., Hellwig, D., Samnick, S. et al. Striatal FP-CIT uptake differs in the subtypes of early Parkinson’s disease. J Neural Transm 114, 331–335 (2007). https://doi.org/10.1007/s00702-006-0518-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-006-0518-2

Navigation