Abstract.
Through electrodes implanted for deep brain stimulation in three patients (5 sides) with Parkinson's disease, we recorded the electrical activity from the human basal ganglia before, during and after voluntary contralateral finger movements, before and after L-DOPA. We analysed the movement-related spectral changes in the electroencephalographic signal from the subthalamic nucleus (STN) and from the internal globus pallidus (GPi). Before, during and after voluntary movements, signals arising from the human basal ganglia contained two main frequencies: a high β (around 26 Hz), and a low β (around 18 Hz). The high β (around 26 Hz) power decreased in the STN and GPi, whereas the low β (around 18 Hz) power decrease was consistently found only in the GPi. Both frequencies changed their power with a specific temporal modulation related to the different movement phases. L-DOPA specifically and selectively influenced the spectral power changes in these two signal bands.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Correspondence to A. Priori
Rights and permissions
About this article
Cite this article
Priori, A., Foffani, G., Pesenti, A. et al. Movement-related modulation of neural activity in human basal ganglia and its L-DOPA dependency: recordings from deep brain stimulation electrodes in patients with Parkinson's disease. Neurol Sci 23 (Suppl 2), s101–s102 (2002). https://doi.org/10.1007/s100720200089
Issue Date:
DOI: https://doi.org/10.1007/s100720200089