Clinical study
Long-term follow-up study of periarteritis nodosa

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Abstract

The records of 130 patients with histologically proved periarteritis nodosa seen at the Mayo Clinic from 1946 through 1962 were reviewed. Intensive corticosteroid or ACTH therapy had been given to 110 of these patients. The expected survivorship, calculated by the life-table method, revealed a five year survival of 48 per cent for the treated patients and 13 per cent for the untreated ones. The presence of hypertension or renal disease at the initial examination seemed to worsen the prognosis. Both disorders were less frequent in patients who had received steroid therapy early in the course of their disease. Subdivision, on clinical grounds, into those with and without pulmonary involvement appeared to have no value in regard to the prognosis. Early and vigorous steroid therapy was of significant value in improving the results in patients with periarteritis nodosa. The majority of patients had to continue this treatment on a long-term basis to suppress symptoms or to prevent exacerbations. Side effects were infrequent.

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    From the Section of Medicine, Mayo Clinic and Mayo Foundation, and the Mayo Graduate School of Medicine (University of Minnesota), Rochester, Minnesota.

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