Pharmacologic aspects of S-adenosylmethionine: Pharmacokinetics and pharmacodynamics

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Abstract

Several studies in animals have shown the efficacy of parenteral S-adenosylmethionine (SAMe) as an anti-inflammatory drug. In this article, data are reported on plasma kinetics, distribution, and metabolism of SAMe after oral administration since preference is given to oral dosage in the usual clinical practice. The results demonstrate the intestinal absorption of SAMe and its active metabolism. Experiments confirm the anti-inflammatory activity of the drug by the oral route. Results are also reported on the analgesic effect of SAMe.

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      It has previously been demonstrated that uptake of AdoMet was three times faster than AdoMet synthesis (Goldberg et al., 1998). The fact that the serum concentration of AdoMet (70 nm; Stramentinoli, 1987) is higher than that of methionine (26 nm; Blom et al., 1989) also argues for the premise that cellular uptake of AdoMet, but not methionine, is biologically reasonable. In Trypanosoma, the AdoMet level is not regulated by the product inhibition of MAT, but probably by transporter activities (Goldberg et al., 1997, 1998).

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