Original articleA disturbance in the control of muscle force in neuroleptic-naive schizophrenic patients
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Movement disorder and sensorimotor abnormalities in schizophrenia and other psychoses - European consensus on assessment and perspectives
2020, European NeuropsychopharmacologyInstrument-based assessment of motor function yields no evidence of dyskinesia in adult first-degree biological relatives of individuals with schizophrenia and schizoaffective disorder
2019, Psychiatry ResearchCitation Excerpt :ANJ during handwriting and force variability during constant application of pressure are both measures of subtle dyskinesia wherein the fluidity of these motor behaviors is disrupted by discoordinated and irregular muscle activity. However, ANJ during handwriting is believed to result from failure to control the timing and contraction of multiple muscle groups within the hand and wrist during movement (Teulings et al., 1997), while maintenance of muscle force steadiness demands controlled contraction of a single agonist-antagonist pair in the absence of proprioceptive feedback (see Caligiuri and Lohr, 1994; Mittal et al., 2011 for discussion). One alternative interpretation of the current findings, then, is that the current study's lack of increased ANJ during handwriting in relatives and the higher incidence of increased force variability during constant pressure exertion in relatives versus controls reported by Koning et al. (2011) could point to the presence of dyskinesia in relatives when subjected to more demanding neuromuscular control tasks.
Neurological soft signs in bipolar and unipolar disorder: A case-control study
2018, Psychiatry ResearchCitation Excerpt :With regard to the question of whether NSS are medication-dependent phenomena, many studies have previously shown that neurological soft signs are present in schizophrenic patients before the exposure to medication (Browne et al., 2000; Dazzan and Murray, 2002). Most studies aiming at the effect of medication on neurological soft signs have argued against such a relation (Caligiuri and Lohr, 1994; Gupta et al., 1995). For instance, previous studies on schizophrenic patients have shown no significant correlation between medications and NSS score (Schröder et al., 1992; Gupta et al., 1995).
Standing postural instability in patients with schizophrenia: Relationships with psychiatric symptoms, anxiety, and the use of neuroleptic medications
2015, Gait and PostureCitation Excerpt :Since all our patients used antipsychotic agents, it is unknown if postural instability was due to schizophrenia only or schizophrenia combined with side effects of neuroleptic medications. However, it has been reported that the problem of muscular power control also exists in drug-free patients with schizophrenia [29], suggesting that postural instability is caused mainly by the disease. Longitudinal data reflecting the influence of medical treatment on psychiatric symptoms are needed to clarify the abnormalities of posture in patients with schizophrenia.
Abnormal white matter integrity in antipsychotic-naïve first-episode psychosis patients assessed by a DTI principal component analysis
2015, Schizophrenia ResearchCitation Excerpt :The fourth factor encompasses tracts in the brainstem such as the inferior and superior cerebellar peduncles. The anomalies in the cerebellar peduncles may help explain the higher degree of postural instability in patients with schizophrenia, compared with healthy individuals (Caligiuri and Lohr, 1994; Marvel et al., 2004; Kent et al., 2012). Wang et al. (2003) specifically studied the FA of the cerebellar peduncles in patients with schizophrenia and did not find any difference from controls.