Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia

doi:10.1016/0006-8993(92)91076-Q

Brain Research

Volume 590, Issues 1–2, 11 September 1992, Pages 13-17

https://doi.org/10.1016/0006-8993(92)91076-Q Get rights and content

Abstract

GABAergic inhibitory mechanisms may offer protection to neurons after global ischemia. We tested the effects of γ-vinyl GABA, a GABA-transaminase inhibitor, via continuous infusion in the third ventricle (Alza pumps) in a gerbil model of repetitive forebrain ischemia. We used two episodes of 3 min duration with a ’reperfusion’ interval of 1 h between the insults. Histological analysis was done with silver staining 5 days after the insult. Our results show that there is significant protection of the hippocampus CA1 region and substantia nigra reticulata in treated animals compared to controls. An increase in GABA levels, decrease in glutamate, or mild hypothermia, may be potential mechanisms for this protection. GABAergic agents may prove useful agents in repetitive ischemia.

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Research reportGamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia

Abstract

Brain Res.

Brain Res.

Brain Res.

Neuroscience

Neurosci. Lett.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Biochem. Pharmacol.

Ischemic damage in the CA1 region of the hippocampus is dependent on glutamate release and intact innervation of from CA3

J. Cereb. Blood Flow Metab.

Hypothermia but not NMDA antagonist MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

J. Neurosci.

Small differences in intraischemic temperatures critically determine the extent of ischemic neuronal injury

J. Cereb. Blood Flow Metab.

Effects of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain

Stroke

The neuropathology of vigabatrin

Epilepsia

Methods of antagonizing glutamate neurotoxicity

Cereb. Brain Metab. Rev.

Mild hypothermic intervention after graded ischemic stress in rats

Stroke

Conditions for pharmacological evaluation in the gerbil model of forebrain ischemia

Stroke

Selective neuronal death after transient forebrain ischemia in the mongolian gerbil: a silver impregnation study

Neuroscience

Determination of transmitter aminoacid turnover

Biochemistry, anatomy and pharmacology of GABA neurons

A reliable method to localize axonal damage after axotomy

Stain Tech.

A reliable and sensitive method to localize terminal degeneration and lysosomes in the central nervous system

Stain Tech.

Research report
Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia