Research article
Spasm of fixation: A quantitative study

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Abstract

Spasm of fixation, consisting of impaired initiation of saccades in the presence of fixation target, but normal initiation in the absence of a fixation target, was measured in a patient with cerebral hemispheric damage. When a central target was constantly present, the patient made horizontal saccades to the sudden appearance of a second target at very prolonged latencies (mean 369 ms). In the absence of a central fixation target, saccadic latency decreased to normal (197 ms). Extinction of a target for a gap interval elicited very short latency movements (122 ms), termed express saccades. The intervals between self-paced horizontal refixation saccades with the head immobile were prolonged, whereas voluntary refixation saccades with the head free to move occurred at shorter intervals. We postulate that cerebral hemispheric damage may cause spasm of visual fixation by disinhibiting the substantia nigra pars reticulata, thereby inhibiting the superior colliculus.

References (35)

  • J.E. Alfano

    Spasm of fixation

    Am. J. Ophthamol.

    (1955)
  • F. Michel et al.

    Trouble de l'orientation visuelle dans les trois dimensions de l'espace

    Cortex

    (1965)
  • F. Monaco et al.

    Acquired ocular motor apraxia and right-sided cortical angioma

    Cortex

    (1980)
  • C.J. Bruce et al.

    Primate frontal eye fields. I. Single neurons discharging before saccades

    J. Neurophysiol.

    (1985)
  • D.G. Cogan et al.

    A type of paralysis of conjugate gaze (ocular motor apraxia)

    Arch. Ophthalmol.

    (1953)
  • D. Denny-Brown

    Spasm of visual fixation

  • RG Fairello et al.

    Generalized cortical electrodecremental event

    Arch. Neurol.

    (1979)
  • B. Fischer et al.

    Human express saccades: extremely short reaction times of goal-directed eye movements

    Exp. Brain Res.

    (1984)
  • B. Fischer et al.

    Human express saccades: effects of randomization and daily practice

    Exp. Brain Res.

    (1986)
  • K. Gale

    Role of the substantia nigra in GABA-mediated anticonvulsant actions

    Adv. Neurol

    (1986)
  • M.E. Goldberg et al.

    The effect of attentive fixation on eye movements evoked by electrical stimulation of the frontal eye fields

    Exp. Brain Res.

    (1986)
  • H. Hecaen et al.

    Balint's syndrome (psychic paralysis of visual fixation) and its minor forms

    Brain

    (1954)
  • O. Hikosaka et al.

    Visual and oculomotor functions of monkey substantia nigra pars reticulata. IV. Relation of substantia nigra to superior colliculus

    J. Neurophysiol.

    (1983)
  • O. Hikosaka et al.

    Modification of saccadic eye movements by GABA-related substances. I. Effect of muscimol and bicuculline in monkey superior colliculus

    J. Neurophysiol.

    (1985)
  • O. Hikosaka et al.

    Modification of saccadic eye movements by GABA-related substances. II. Effects of muscimol in monkey substantia nigra pars reticulata

    J. Neurophysiol

    (1985)
  • O. Hikosaka et al.

    Functional properties of monkey caudate neurons

    J. Neurophysiol

    (1989)
  • G. Holmes

    Spasm of fixation

    Trans. Ophthalmol. Soc. U.K.

    (1930)
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