Neuropsychological and cerebral metabolic function in early vs late onset dementia of the Alzheimer type
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Cited by (81)
Resting-state EEG alpha/theta power ratio discriminates early-onset Alzheimer's disease from healthy controls
2021, Clinical NeurophysiologyCitation Excerpt :Several studies have shown that, while memory impairments are common in LOAD, impairments in attention, language, and visuospatial abilities are more prominent in EOAD (Galton et al., 2000; Greicius et al., 2002; Koedam et al., 2010; Smits et al., 2012). However, in some studies, it is reported that the age of onset does not relate to impaired cognitive areas (Seltzer and Sherwin, 1983; Grady et al., 1987). Magnetic Resonance Imaging (MRI) studies showed that neocortical atrophy in EOAD is greater than LOAD (Ishii et al., 2005; Möller et al., 2013; Hamelin et al., 2015; Migliaccio et al., 2015).
Early-onset and late-onset Alzheimer's disease are associated with distinct patterns of memory impairment
2016, CortexCitation Excerpt :Briefer evolution in early-onset patients was later confirmed (Jacobs et al., 1994), but there have been conflicting results in the literature regarding the nature of the cognitive decline. Several studies did not find any distinctive differences between EOAD and LOAD patients (Bayles, Kaszniak, & Tomoeda, 1987; Cummings, Benson, Hill, & Read, 1985; Grady, Haxby, Horwitz, Berg, & Rapoport, 1987; Selnes, Carson, Rovner, & Gordon, 1988; Toyota et al., 2007) or have attributed such differences to dementia severity (Jacobs et al., 1994; Smits et al., 2012). Regarding memory, a relative sparing of memory in EOAD has been reported (Binetti et al., 1996; Smits et al., 2012), while several studies have found that LOAD patients present primarily with memory difficulties (Imamura et al., 1998; Jacobs et al., 1994).
Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset
2015, Alzheimer's and DementiaCitation Excerpt :Others have demonstrated that those with younger onset have shorter digit spans [33–35] and poorer performance drawing pentagons [36]. Our results differ from those of two studies which found no significant differences between older and younger onset cases in any neuropsychological test performed in their study including language, visuospatial, and attention tasks [37,38]. However, both of these studies were performed using smaller sample sizes, potentially limiting the power to detect differences.
Staging Alzheimer's disease progression with multimodality neuroimaging
2011, Progress in NeurobiologyCitation Excerpt :In groups of patients with comparable levels of cognitive decline, the average gray matter loss was 19.5% in early-onset AD but only about half as great (11.9%) in late-onset AD, relative to appropriately matched healthy controls. Interestingly, not only was tissue loss more severe in early- versus late-onset AD, but neocortical regions were more affected in early-onset and medial temporal regions in late-onset patients (Frisoni et al., 2007, 2005; Grady et al., 1987; Seltzer and Sherwin, 1983). This agrees with neuropsychological studies indicating that neocortical functions (aphasia, apraxia, agnosia) are more affected in early-onset AD and medial temporal functions (verbal and non-verbal learning) in late-onset AD (Grady et al., 1987; Jacobs et al., 1994).
Focal posterior cingulate atrophy in incipient Alzheimer's disease
2010, Neurobiology of AgingCitation Excerpt :In fact, if anything, there was evidence that the magnitude of atrophy in BA 29/30 was greater in late-onset disease. Failure to demonstrate an association between early-onset AD and disproportionate posterior cingulate atrophy is consistent with evidence from FDG-PET (Grady et al., 1987) and neuropathology (Armstrong et al., 2000) that also failed to find these age-related subtypes. Despite the present study's design advantages over some VBM reports for studying incipient AD, certain limitations warrant mention.