Cerebral glucose consumption measured by PET in patients with and without psychiatric symptoms of Huntington's disease
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Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease
2017, Progress in NeurobiologyCitation Excerpt :SPECT studies show reduced blood flow in the cerebral cortex of pre-symptomatic HD individuals (Hasselbalch et al., 1992; Sax et al., 1996), which precedes cortical atrophy as evaluated by MRI (Jernigan et al., 1991). Moreover, PET studies have identified a reduced glucose uptake and metabolism in pre-symptomatic HD cerebral cortex (Hayden et al., 1986; Kuwert et al., 1989; Clark et al., 1991; Jenkins et al., 1998), indicating altered neuronal activity. Uric acid, glutathionine, and kyruneric acid, an antagonist of excitatory amino acid receptors, were also found to be reduced in HD post-mortem cortical tissue using high-performance liquid chromatography (Beal et al., 1992).
In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease
2016, NeuroImageCitation Excerpt :Defects in brain energy metabolism have been consistently found in HD patients and animal models. In particular, Positron Emission Tomography (PET) studies demonstrated large reduction in glucose consumption in the caudate/putamen in HD patients (Brouillet et al., 1999; Kuwert et al., 1989, 1990). Nonetheless, non-invasive in vivo methods to more broadly characterize energy metabolism in HD are rare.
PET: A revolution in medical imaging
2004, Radiologic Clinics of North AmericaImplications of PET Based Molecular Imaging on the Current and Future Practice of Medicine
2004, Seminars in Nuclear MedicineCitation Excerpt :Clearly, the introduction of molecular imaging techniques has revolutionized the field of oncology, which in turn has substantially contributed to the growth of the field of nuclear medicine.48 In particular, FDG-PET has definitely become necessary for the treatment of a variety of malignancies.48–51 Although FDG-PET plays an important role in staging various malignancies, its role in the diagnosis of cancer is limited at this time because most malignancies are diagnosed before FDG-PET is considered.
Determination of regional cerebral function with FDG-PET imaging in neuropsychiatric disorders
2002, Seminars in Nuclear Medicine