Circadian pattern of motor activity in major depressed patients undergoing antidepressant therapy: Relationship between actigraphic measures and clinical course
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2019, Behavioural Brain ResearchCitation Excerpt :At the central level, the amplitude of the daily rhythmic concentrations of the hypothalamic neuropeptide orexin (ORX) in the cerebrospinal fluid and the number of immunoreactive ORX cells (postmortem) are also down regulated in depressive patients [31–33]. Because ORX is implicated in the induction of arousal and awakening, the downregulated amplitude of ORX daily rhythms might be an important neurobiological change that leads in the reduction of the locomotor activity rhythms and sleep disturbances in MDD [29,34]. Furthermore, both the mRNA and protein levels of the glutamic acid decarboxylase (GAD) 65/67 and AVP are significantly increased in the postmortem hypothalamic SCN of depressive subjects (in a sex-dependent manner) in comparison to healthy controls [35,36].
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2017, Psychiatry ResearchCitation Excerpt :Later in the therapy process, these activities feel “as pleasant as before depression” again. Other studies have found higher levels of motor activity per se (not necessarily judged as pleasant by the patient) related to the antidepressant response (Godfrey and Knight, 1984; Pjrek, 2003; Raoux et al., 1994; Todder et al., 2009). There is consensus about the positive impact of physical exercise (in the sense of sports) on depression.