Chromosome abnormalities in low-grade central nervous system tumors

doi:10.1016/0165-4608(92)90235-Z

Cancer Genetics and Cytogenetics

Volume 60, Issue 1, May 1992, Pages 67-73

https://doi.org/10.1016/0165-4608(92)90235-Z Get rights and content

Abstract

Ependymomas, oligodendrogliomas, and low-grade astrocytomas are slow-growing central nervous system (CNS) tumors that occur in both adults and children, whereas craniopharyngiomas and choroid plexus papillomas occur predominantly in children. We examined karyotypes of 32 of these low-grade tumors, including ten oligodendrogliomas, six ependymomas, 11 low-grade astrocytomas, four craniopharyngiomas, and one choroid plexus papilloma. Only normal karyotypes were obtained from 6 oligodendrogliomas. The rest had normal stemlines; three tumors had 45,X,−Y sidelines and one tumor had a sideline of monosomy 22. The most frequent abnormalities in the ependymomas were +7 (three tumors), −21 (two tumors), −22 (two tumors), and del(9)(p22) (two tumors). Gains of chromosome 7 and deletions of 9p were found more often in high-grade gliomas. Seven low-grade astrocytomas had normal stemlines, two had chromosome 7 abnormalities, a pilocystic astrocytoma had +der(15), and one tumor had a −Y sideline. The four craniopharyngiomas and one choroid plexus tumor were all apparently normal. The cytogenetics of low-grade CNS tumors differ from higher grade gliomas in that most low-grade tumors show little deviation from the normal karyotype.

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^☆: Supported by an American Cancer Society Clinical Oncology Career Development Award to (C. G.), a grant from the American Cancer Society Maryland Division, funds from the Andrew W. Mellon Foundation, and Grants No. CA 46289-03 and U01 CA52857 from NIH.

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Chromosome abnormalities in low-grade central nervous system tumors☆

Abstract

Cancer Genet Cytogenet

Cancer Genet Cytogenet

Cancer Genet Cytogenet

Cancer Genet Cytogenet

Cancer Res

Cancer Genet Cytogenet

Acta Pathol Microbiol Immunol Scand [A]

Specific chromosomal abnormalities in malignant human gliomas

Cancer Res