Chromosome abnormalities in low-grade central nervous system tumors☆
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Cited by (100)
Histology and molecular aspects of central neurocytoma
2015, Neurosurgery Clinics of North AmericaCitation Excerpt :Taruscio and colleagues12 found nonrandom gains in chromosome 7 in 3 of 9 (33%) tumor specimens using fluorescent in situ hybridization. As noted by the investigators, trisomy 7 has been identified in a variety of intracranial tumors, including low-grade and high-grade gliomas and primitive neuroectodermal tumors,37–40 as well as in renal, lung, and bladder tumors.41–43 Trisomy 7 has also been associated with nonneoplastic diseases as well as normal tissues, including brain tissues.44–46
Pediatric low-grade gliomas: How modern biology reshapes the clinical field
2014, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :Early cytogenetic studies revealed almost normal diploid karyotypes across multiple subtypes of PLGGs [174–176]. The most frequent recurrent chromosomal alteration identified was a gain of chromosome 7, especially in PAs [174,177–179]. Other chromosomal structural abnormalities included gains of chromosomes 4, 5, 6, 8, and 11 and deletion of 17p in a subset of PAs, inversion in chromosome 8, and loss of chromosome 1q [174,177–185].
A break-apart fluorescence in situ hybridization assay for detecting RET translocations in papillary thyroid carcinoma
2007, Cancer Genetics and CytogeneticsCitation Excerpt :RAJI cells were used as a negative control for RET rearrangement detected by PCR. G-banding was performed using standard methods [19]. SKY analysis was performed on air-dried slides made from standard cytogenetic harvests and hybridized according to the protocol supplied by the probe manufacturer (Applied Spectral Imaging, Inc., Carlsbad, CA, USA).
Genomic alterations of adamantinomatous and papillary craniopharyngioma
2017, Journal of Neuropathology and Experimental NeurologyNovel fusion genes and chimeric transcripts in ependymal tumors
2016, Genes Chromosomes and CancerCraniopharyngioma: Pathological and molecular aspects
2016, Diagnosis and Management of Craniopharyngiomas
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Supported by an American Cancer Society Clinical Oncology Career Development Award to (C. G.), a grant from the American Cancer Society Maryland Division, funds from the Andrew W. Mellon Foundation, and Grants No. CA 46289-03 and U01 CA52857 from NIH.