Research paperThe N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat
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Inducible expression of antigens in plants: a study focused on peptides related to multiple sclerosis immunotherapy
2020, Journal of BiotechnologyCitation Excerpt :Initially during the inflammatory phase of MS; active T-cells against myelin basic protein (MBP), proteolipid protein (PLP), and myelin oligodendrocyte glycoprotein (MOG) contribute directly to the progression of the disease (Bielekova et al. 2004; Lunemann et al. 2004). The presence of autoreactive T-cells against myelin antigens (i.e. MBP, PLP, and MOG) is clearly associated to the disease and cell transfer assays have proven that these cells result in experimental autoimmune encephalomyelitis (EAE) in animal models (Adelmann et al. 1995; Whitham et al., 1991). Years of study have shown that pathogenic T-cells appear as result of reduced supression mediated by CD4+ CD25 + T regulatory cells (Tregs) (Viglietta et al. 2004), interleukin (IL)-10 release (Vandenbark et al. 2001), and possibly CD8 + T suppressor cells (Antel et al. 1986; Huan et al. 2005).
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity
2020, ImmunityCitation Excerpt :Multiple lines of evidence suggest that IGF ligands are present in the central nervous system (CNS) during active inflammation in the EAE model of MS and affect disease severity, although the mechanisms are not well defined (Liu et al., 1994; Lovett-Racke et al., 1998; Spath et al., 2017). To test whether expression of IGF1R directly influences Th17 versus Treg cell differentiation under inflammatory conditions in vivo, we immunized Igf1rΔCD4 and control littermate mice with Myelin oligodendrocyte glycoprotein (MOG) peptide to induce EAE (Adelmann et al., 1995). Mice lacking expression of IGF1R on T cells were protected from disease and demonstrated reduced weight loss, peak and final clinical scores, and histopathology (Figures 3A–3E).
Animal Models of Autoimmunity
2016, Encyclopedia of Immunobiology