Trends in Neurosciences
Volume 16, Issue 9, September 1993, Pages 353-359
Journal home page for Trends in Neurosciences

Review
Nerve growth factor and nociception

https://doi.org/10.1016/0166-2236(93)90092-ZGet rights and content

Abstract

Nerve growth factor (NGF) is thought of as a target-derived factor responsible for the survival and maintaining the phenotype of specific sets of peripheral and central neurons during development and maturation. Recently, using physiological techniques, we have shown that specific functional types of nociceptive sensory neurons require NGF, first for survival during development in utero and then for their normal phenotypic development (but not survival) in the early postnatal period. In adulthood, the physiological role of NGF changes dramatically and here it may serve as a link between inflammation and hyperalgesia. Despite apparent changes in NGF's mode of action as the animal matures, it always interacts specifically with nociceptive sensory neurons.

References (65)

  • Y-A. Barde

    Neuron

    (1989)
  • P.D. Gorin et al.

    Brain Res.

    (1980)
  • U. Otten

    Trends Pharmacol. Sci.

    (1984)
  • E.M. Johnson et al.

    Trends Neurosci.

    (1986)
  • S.L. Carroll

    Neuron

    (1992)
  • J. Winter et al.

    Neuron

    (1988)
  • B.A. Urschel et al.

    Exp. Neurol.

    (1991)
  • A.M. Ritter et al.

    Brain Res. Bull.

    (1993)
  • P. Kenins

    Neurosci. Lett.

    (1981)
  • R.D. Treede et al.

    Prog. Neurobiol.

    (1992)
  • J. Donnerer et al.

    Neuroscience

    (1992)
  • K. Yoshida et al.

    Brain Res.

    (1992)
  • E. DiMarco

    J. Biol. Chem.

    (1991)
  • L. Aloe et al.

    Brain Res.

    (1977)
  • N. Mazurek et al.

    FEBS Lett.

    (1986)
  • R.M. Lindsay et al.

    Neuroscience

    (1989)
  • Y. Kuraishi

    Peptides

    (1989)
  • M.G. Garry et al.

    Brain Res.

    (1992)
  • P.J. Hope et al.

    Brain Res.

    (1990)
  • M. Randic et al.

    Neurosci. Lett.

    (1990)
  • R. Dubner et al.

    Trends Neurosci.

    (1992)
  • P. Reeh et al.

    Brain Res.

    (1986)
  • K.G. Ruit et al.

    J. Neurosci.

    (1990)
  • G.R. Lewin et al.

    J. Neurosci.

    (1992)
  • M. Goedert et al.
  • V.M. Verge et al.

    J. Neurocytol.

    (1989)
  • M. Goedert
  • P. Holzer

    Pharmacol. Rev.

    (1991)
  • S.P. Hunt et al.
  • L. Aloe et al.

    Nature

    (1981)
  • J.D. Leah et al.

    Neurosci. Lett.

    (1987)
  • A.M. Ritter et al.

    Nature

    (1991)
  • Cited by (0)

    View full text