Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

doi:10.1016/0167-5699(93)90235-D

Immunology Today

Volume 14, Issue 7, July 1993, Pages 353-356

Immunology Today

https://doi.org/10.1016/0167-5699(93)90235-D Get rights and content

Abstract

Pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell-mediated immunity. Since T_H1 cytokines compromise pregnancy and T_H2 cytokines are produced at the maternal-fetal interface, we hypothesize that these T_H2 cytokines inhibit T_H1 responses, improving fetal survival but impairing responses against some pathogens.

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viewpointBidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

Abstract

Cell Immunol.

Blood

Cell Immunol.

J. Reprod. Immunol.

Adv. Immunol.

Immunol. Today

J. Reprod. Immunol.

J. Immunol.

Reg. Immunol.

J. Reprod. Fertil.

J. Immunol.

Biol. Reprod.

J. Reprod. Fertil.

Nature

Biol. Reprod.

Am. J. Reprod. Immunol.

Clin. Rheumatol.

Semin. Perinatol.

viewpoint
Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a T_H2 phenomenon?