Elsevier

Neurobiology of Aging

Volume 13, Issue 4, July–August 1992, Pages 483-491
Neurobiology of Aging

Reduced temporal lobe blood flow in alzheimer's disease

https://doi.org/10.1016/0197-4580(92)90076-AGet rights and content

Abstract

We used single photon emission computed tomography with the blood flow tracer [123I]N-isopropylP-iodoamphetamine (IMP) to study regional cerebral blood flow (rCBF) in 50 mildly and moderately demented Alzheimer's disease (AD) patients to evaluate rCBF as a function of disease severity. Relative rCBF (normalized to occipital cortex) was significantly lower than controls in temporal cortex for both mildly and moderately demented patients. Similar numbers of patients in both groups demonstrated perfusion abnormalities in temporal neocortex. Parietal cortex was more variably involved with greater numbers of moderately than mildly demented patients showing perfusion abnormalities. Relative rCBF in dirsolateral frontal cortex was reduced only in the moderately demented patients. Disease severity, as measured by the Mini Mental Status Examination, was associated with relative rCBF only in dorsolateral frontal and parietal cortex. These results suggest that the temporal lobes are the first neocortical regions affected by AD and that other cortical areas become involved as the disease progresses.

References (75)

  • G.K. Wilcock et al.

    Plaques, tangles and dementia

    J. Neurol. Sci.

    (1982)
  • S.E. Arnold et al.

    The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease

    Cereb. Cortex

    (1991)
  • A.L. Benton et al.

    Multilingual aphasia examination (revised)

    (1983)
  • F.J. Bonte et al.

    SPECT study of regional cerebral blood flow in Alzheimer's disease

    J. Comp. Assist. Tomogr.

    (1986)
  • D.M. Bowen et al.

    Accelerated ageing or selective neuronal loss as an important cause of dementia?

    Lancet

    (1979)
  • D.R. Brady et al.

    Amygdaloid pathology in Alzheimer's disease: Qualitative and quantitative analysis

    Dementia

    (1990)
  • A. Brun et al.

    Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading

    Histopathology

    (1981)
  • A. Brun et al.

    Distribution of cerebral degeneration in Alzheimer's disease

    Arch. Psychiat. Nervenkr.

    (1976)
  • A. Burns et al.

    The investigation of Alzheimer's disease with single photon emission tomography

    J. Neurol. Neurosurg. Psychiatry

    (1989)
  • T.N. Chase et al.

    Wechsler Adult Intelligence Scale performance: Cortical localization by fluorodeoxyglucose F18 positron emission tomography

    Arch. Neurol.

    (1984)
  • D.R. Crapper McLachlan et al.

    Alzheimer's disease: Clinical course and cognitive disturbances

    Acta Neurol. Scand.

    (1984)
  • S. de la Monte

    Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer's disease

    Ann. Neurol.

    (1989)
  • D.C. Delis et al.

    The California verbal learning test

    (1987)
  • G. Deutsch et al.

    Cerebral blood flow in severitymatched Alzheimer and multi-infarct patients

    Neurology

    (1987)
  • R. Duara et al.

    Positron emission tomography in Alzheimer's disease

    Neurology

    (1986)
  • M.M. Esiri et al.

    A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease

    J. Neurol. Neurosurg. Psychiatry

    (1990)
  • N.L. Foster et al.

    Alzheimer's disease: Focal cortical changes shown by positron emission tomography

    Neurology

    (1983)
  • N.L. Foster et al.

    Cortical abnormalities in Alzheimer's disease

    Ann. Neurol.

    (1984)
  • R.S.J. Frackowiak et al.

    Regional cerebral oxygen supply and utilization in dementia: A clinical and physiological study with oxygen-15 and positron tomography

    Brain

    (1981)
  • H.G. Gemmel et al.

    Cerebral blood flow measured by SPECT as a diagnostic tool in the study of dementia

    Psychiatry Res.

    (1989)
  • C.L. Grady et al.

    Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type

    J. Clin. Exp. Neuropsychol.

    (1988)
  • C.L. Grady et al.

    Stability of metabolic and neuropsychological asymmetries in dementia of the Alzheimer type

    Neurology

    (1986)
  • V.C. Hachinski et al.

    Cerebral blood flow in dementia

    Arch. Neurol.

    (1975)
  • J.V. Haxby et al.

    Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer's disease

    J. Cereb. Blood Flow Metab.

    (1985)
  • J.V. Haxby et al.

    Neocortical metabolic abnormalities precede non-memory cognitive defects in early Alzheimer's-type dementia

    Arch. Neurol.

    (1986)
  • J.V. Haxby et al.

    Heterogeneous anterior-posterior metabolic patterns in dementia of the Alzheimer type

    Neurology

    (1988)
  • M. Hooper et al.

    The limbic system in Alzheimer's disease

    Am. J. Pathol.

    (1976)
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