Elsevier

Neuroscience Letters

Volume 185, Issue 1, 6 February 1995, Pages 13-15
Neuroscience Letters

Apolipoprotein E polymorphism and Alzheimer's disease in Eastern Finland

https://doi.org/10.1016/0304-3940(94)11213-3Get rights and content

Abstract

Apolipoprotein E is a polymorphic protein defined by three alleles, ε2, ε3 and ε4. An increased frequency of the ε4 allele is associated with late-onset familial and sporadic Alzheimer's disease (AD). We studied 202 Finnish AD patients and 55 age- and sex-matched controls. AD patients were divided into four subgroups; sporadic early-onset, sporadic late-onset, familial early-onset and familial late-onset disease. We found no significant differences in the ε4 allele frequency between the subgroups. However, all the subgroups differed in the frequency of ε4 allele detection from the controls (P < 0.0001). In the late-onset patients, the age at onset decreased from 76 to 69 as the number of ε4 alleles increased from 0 to 2.

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    This study was supported by the Medical Research Council of the Academy of Finland.

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