Short communicationImmunization of pigs with culture antigens of Taenia solium
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Cited by (37)
Taenia solium taeniasis/cysticercosis: From parasite biology and immunology to diagnosis and control
2021, Advances in ParasitologyCitation Excerpt :The authors suggested, based on these findings, that pigs are more adapted to larval-stage infection (as they are the natural intermediate host), although the authors did not control for the time of exposure. The efficiency of establishment of T. solium eggs in the porcine host (proportion of eggs establishing and developing to metacestode infection) ranges from 0.94% to 5% of all ingested eggs using an 8400–15,000 egg input (Flisser et al., 1979; Kumar et al., 1987; Molinari et al., 1983; Nascimento et al., 1995; Pathak and Gaur, 1990). Tsang et al. (1991) identified a 0.28% infection efficiency using 10–20,000 eggs with 20% viability.
The highly antigenic 53/25kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigs
2012, Veterinary Immunology and ImmunopathologyCitation Excerpt :Vaccines are crucial to achieve sustained control and possible eradication of this disease. Oncosphere antigens are currently the most effective vaccine candidates in preventing porcine cysticercosis (Assana et al., 2010; Flisser et al., 2004; Gonzalez et al., 2005; Lightowlers et al., 2003; Pathak and Gaur, 1990; Plancarte et al., 1999; Verastegui et al., 2002). T. solium oncospheral protein TSOL18 is currently the best antigen able to induce near total protection against a T. solium proglottid oral challenge in pigs (Lightowlers, 2003).
Characterization of a novel Taenia solium oncosphere antigen
2007, Molecular and Biochemical ParasitologyVaccination against cestode parasites: Anti-helminth vaccines that work and why
2003, Veterinary ParasitologyVaccines for prevention of cysticercosis
2003, Acta TropicaCitation Excerpt :Two of these T. saginata antigens were able to be used together to induce very high levels of protection against experimental challenge infection with T. saginata eggs in cattle. In common with all other taeniid cestodes which have been investigated, oncosphere antigens of T. solium have been found to be a rich source of host-protective antigens (Pathak and Gaur, 1990; Plancarte et al., 1999; Verastegui et al., 2002). The rapid success which had been achieved with identifying host-protective recombinant antigens for T. saginata, encouraged the adoption of a similar approach for development of a vaccine against T. solium cysticercosis in pigs.