Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease
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2019, Behavioural Brain ResearchCitation Excerpt :Changes in the glutamatergic signaling are seen in aging. For example, patients with dementia showed reduced glutamate levels in the CSF [51] and in post-mortem brain [52]. Preclinical studies also suggest that N-methyl-D-aspartate (NMDA) receptor hypofunction is associated with cognitive impairment in aging.
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2017, Neurochemistry InternationalCitation Excerpt :In the PD field this has led most studies to instead pursue transplantation of cells into the striatum, the target of dopaminergic innervation, rather than the substantia nigra where the disease-affected neurons normally reside. In the case of other neurodegenerative disease that exhibit more widespread pathology and loss of varying neuronal subtypes in multiple brain regions, such as AD, this kind of neuronal replacement paradigm becomes even more challenging (Davies and Maloney, 1976; Davies et al., 1980; Hardy et al., 1987; Hyman et al., 1987; Lowe et al., 1990). How then can NSCs be a reasonable therapy for these more complex neurodegenerative disorders?
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2016, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :These reactions could alter the glutamate/glutamine balance, which could help explain the elevated glutamate levels seen in CG in this study. We note that other reports of changes in glutamate levels in the AD-brain are contradictory, possibly due to general differences in the measurements performed in ante-mortem and post-mortem tissue [38,39]. An alternative route of glutamate metabolism is via transamination, which involves two linked transamination reactions.
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Present address: Institute of Molecular and Cell Biology, National University of Singapore, 10 Kent Ridge Crescent, 0511 Singapore.