Elsevier

Neuroscience

Volume 62, Issue 2, September 1994, Pages 327-331
Neuroscience

Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity

https://doi.org/10.1016/0306-4522(94)90366-2Get rights and content

Abstract

Experimental inflammation produced by an intraplantar injection of complete Freund's adjuvant results in local sensory hypersensitivity and up-regulates the neuropeptides substance P and calcitonin gene related peptide in the primary sensory neurons innervating the inflamed tissue. The inflammation also elevates nerve growth factor levels in the skin. Systemic administration of anti-NGF neutralizing antibodies prevent the behavioral sensitivity, the up-regulation of neuropeptides and the inflammation-induced expression of the immediate early gene c-fos in dorsal horn neurons, without modifying swelling and erythema. Elevation of the neurotrophin NGF in the periphery is a major contributor, therefore, of inflammatory pain.

Reference (36)

  • MazurekN. et al.

    Nerve growth factor induces mast cell degranulation without changing intracellular calcium levels

    Fedn Eur. biochem. Socs Lett.

    (1986)
  • McMahonS.B. et al.

    Expression and coexpression of trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets

    Neuron

    (1994)
  • NoguchiK. et al.

    A noxious stimulus induces the preprotachykinina gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry

    Molec. Brain Res.

    (1988)
  • SmithG.D. et al.

    Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat

    Neurosci. Lett.

    (1992)
  • SteinC. et al.

    Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds

    Pharmac. Biochem. Behav.

    (1988)
  • BischoffS.C. et al.

    Effect of nerve growth factor on the release of inflammatory mediators by mature human basophils

    Blood

    (1992)
  • BohmA. et al.

    Nerve growth factor enhances precocious differentiation and numerical increase in mast cells in cultures of rat splenocytes

    Acad. Naz. Lincei

    (1986)
  • DiamondJ. et al.

    Sensory nerves in adult rat regenerate and restore sensory function to the skin independently of endogenous NGF

    J. Neurosci.

    (1992)
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