Liquid chromatographic determination of a new catechol-O-methyltransferase inhibitor, entacapone, and its Z-isomer in human plasma and urine
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A novel electrochemical nanosensor based on NH <inf>2</inf> -functionalized multi walled carbon nanotubes for the determination of catechol-orto-methyltransferase inhibitor entacapone
2019, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Moreover, mean maximum plasma concentrations (Cmax) of 650–1559 ng.mL−1 (2.13 × 10−6 – 5.11 × 10−6 mol.L−1) are generally reached at (tmax) of 0.70–1.82 h. The elimination of Entacapone is biphasic, with an elimination half-life of 1–2 h [4,5]. The mechanism of action of ENP is believed to occur through its ability of inhibiting COMT and altering the plasma pharmacokinetics of levodopa making it thus bioavailable for prolong therapeutic effect [6,7].
Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: A review
2012, Analytica Chimica ActaCitation Excerpt :The extent to which interconversion, epimerization or E to Z isomerization are minimized depends on experimental conditions during the bioanalytical procedure; interconversion depends on the temperature and pH, whereas epimerization and E to Z isomerization are influenced by pH or light exposure [52]. Thus, in the analysis of COMT inhibitors care must be taken during sample handling and preparation, especially when working with entacapone, because it can isomerize to (Z)-entacapone; this reaction seems to be catalyzed by daylight and plasma proteins, so that sample handling must be rapid and protected from daylight [31,46]. As listed in Table 3, some urine samples have only been diluted to determine tolcapone and some of its metabolites [30,35].
Development of characterization methods for entacapone in a pharmaceutical bulk
2011, Journal of Pharmaceutical and Biomedical AnalysisDetermination of l-dopa, carbidopa, 3-O-methyldopa and entacapone in human plasma by HPLC-ED
2011, Journal of Pharmaceutical and Biomedical AnalysisSquare-wave adsorptive stripping voltammetric behaviour of entacapone at HMDE and its determination in the presence of surfactants
2010, Colloids and Surfaces A: Physicochemical and Engineering Aspects