Original contributionSpermine: An anti-oxidant and anti-inflammatory agent
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Cited by (92)
A link between urease and polyamine metabolism in Cryptococcus neoformans
2021, Microbial PathogenesisCitation Excerpt :Although rarely observed, some fungi can convert spermidine to spermine by the action of spermine synthase (Fig. 1h). Cellular functions of spermine include mitochondrial calcium transport [23], neutralization of reactive oxygen species [24] and the activation of P-type H + -ATPase involved in fungal morphogenesis [25]. It should be noted that spermine can also be converted back to spermidine and spermidine to putrescine via the enzymes spermidine/spermine N- acetyltransferase and polyamine oxidase (Fig. 1i and j) [15,16].
Essential, deadly, enigmatic: Polyamine metabolism and roles in fungal cells
2019, Fungal Biology ReviewsCitation Excerpt :Spermine enhances H+ pumping and ATP hydrolysis mediated by the membrane P-type H + -ATPase, creating a membrane potential that could orient cell polarization and growth (Jesus et al., 2018). Spermine is also a free radical scavenger and mediates responses to oxidative stress by neutralizing reactive oxygen species (ROS) (Lovaas and Carlin, 1991). Along with Mg2+, spermine mediates Ca2+ mitochondrial transport in the yeast Endomyces magnusii (Fig. 1) (Votyakova et al., 1993).
The old and new biochemistry of polyamines
2018, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :The more amino groups and the longer the chain length of the polyamine, the higher its stability constants for binding metal ions [23]. This chelating efficiency may be responsible for their anti-inflammatory and anti-oxidant functions [113]. Additionally, by displaying metal-chelating properties, polyamines may serve as potential non-transferrin-bound, iron-binding agents [23], although their physiological relevance is unclear.