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Influence of flupirtine on human lower limb reflexes

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Abstract

The influence of a single oral dose (400 mg) of flupirtine on lower limb reflexes was investigated in normal human subjects using H-reflex testing, flexor reflex testing and dynamic posturography. Flupirtine did not significantly change the latency of the H-reflex or the Hmax/Mmax ratio. Both, the first (F1) and the second (F2) components of the flexor reflex were significantly depressed. Flupirtine significantly decreased the size of the ML response following fast transient platform movements rotating toe-up around the ankle joint. We conclude that flupirtine acts on polysynaptic spinal pathways. In addition to its well known analgesic effect flupirtine might have a muscle relaxant effect.

References (29)

  • P.J. Delwaide et al.

    Some pathophysiological aspects of parkinsonian rigidity

    J. Neural Transm.

    (1986)
  • H.C. Diener et al.

    Variability of postural “reflexes” in humans

    Exp. Brain Res.

    (1983)
  • H.C. Diener et al.

    Increased shortening reaction in Parkinson's disease reflects a difficulty in modulating long loop reflexes

    Move. Dis.

    (1987)
  • R. Gordon et al.

    Effect of flupirtine maleate on the nociceptive pathway, EEG, evoked potentials and polysynaptic reflexes in laboratory animals

    Postgrad. Med. J.

    (1987)
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    1

    Present address: R.S. Dow Neurological Sciences Institute, 1120 N.W. 20th Ave., Portland, OR, 97209-1595, USA.

    2

    Present address: Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, Pauwelstraβe 30, D-52057 Aachen, FRG.

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