Disruption of the cytoskeleton in Alzheimer's disease
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Protein phosphatase 2A as therapeutic targets in various disease models
2018, Life SciencesCitation Excerpt :The proposed mechanism of increased miR-1 activity contributes to initiation of arrhythmia in chronic atrial fibrillation due to altered Ca2+ handling and impaired atrial contractility [82]. Tau is a microtubule associated protein which once phosphorylated by kinases is reported to play an important role in regulating axonal microtubule dynamics to support neuronal and synaptic functions [6,49,68,81]. PP2A present in brain dephosphorylate tau and thus play a preventive role.
Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese
2011, Brain ResearchCitation Excerpt :The MAPT H1 haplotype and subhaplotypes may be associated with sporadic tauopathies including AD (Baker et al., 1999; Myers et al., 2005; Pittman et al., 2005; Myers et al., 2007; Kwok et al., 2004; Laws et al., 2007). And that, tau's phosphorylation is regulated by many protein kinases (Lee, 1995), including glycogen synthase kinase 3beta (GSK3B) (Rankin et al., 2007). Glycogen synthase kinase 3 (GSK3) has two homologous isoforms, GSK3A and GSK3B.
Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese
2011, Neuroscience LettersNGF-induced neurite outgrowth of PC12 cells in the presence of phosphatidylcholine hydroperoxides: Implication for ageing
2008, Mechanisms of Ageing and DevelopmentDevelopment, Optimization and Use of Preclinical Behavioral Models to Maximize the Productivity of Drug Discovery for Alzheimer's Disease
2008, Animal and Translational Models for CNS Drug DiscoveryPhosphatases regulate histamine synthesis in rat brain
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