Original articleIntelligence of children of epileptic mothers*
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Cited by (116)
The treatment of epilepsy in pregnancy: The neurodevelopmental risks associated with exposure to antiepileptic drugs
2016, Reproductive ToxicologyChildren (10-12 years age) of women with epilepsy have lower intelligence, attention and memory: Observations from a prospective cohort case control study
2015, Epilepsy ResearchCitation Excerpt :There is growing body of evidence that antenatal exposure to AEDs particularly valproate (VPA) increases the risk for poorer cognitive abilities in children (Adab et al., 2001, 2004; Banach et al., 2010; Gaily et al., 2004; Kantola-Sorsa et al., 2007; Meador et al., 2009; Thomas et al., 2007; Vinten et al., 2009). Recent studies have shown that children of WWE have lower neurodevelopmental/cognitive outcomes at 1 year (Thomas et al., 2008), 2–3 years (Bromley et al., 2010; Cummings et al., 2011; Meador et al., 2009, 2011, 2013; Shallcross et al., 2011) and 6 years (Gaily et al., 1988; Kantola-Sorsa et al., 2007; Nadebaum et al., 2011; Thomas et al., 2007; Vanoverloop et al., 1992). The role of antenatal exposure to specific antiepileptic drugs, dosage and the socio-environmental factors on the long-term neurocognitive outcome of children of women with epilepsy (CWE) remains to be established.
Cognitive outcomes of prenatal antiepileptic drug exposure
2015, Epilepsy ResearchDevelopmental neurotoxicity and anticonvulsant drugs: A possible link
2014, Reproductive ToxicologyCitation Excerpt :LTG has been purported to be devoid of adverse effects on child development [103] and on language skills [12]. Indeed, children exposed to LTG did not differ from those exposed to CBZ or PHT at 3 and 4.5 years of age and also had a better IQ outcome than those exposed to VPA [9,84]. In contrast with these findings, a prospective observation study reported that children born from mothers taking LTG or to VPA during pregnancy were similarly impaired in the non-verbal domain, in motor skills, in sensory measures and in behavioral, attentional and parent-reported executive functions in comparison to non-exposed children.
Anti-epileptic drugs and brain and behavioural development in animal models and humans
2010, Fetal and Maternal Medicine Review
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Supported by the Rinnekoti Research Foundation, Espoo, Finland, the Foundation for Pediatric Research, and the Orion Foundation.
Preliminary results of study presented in part at the Congress of the European Federation of Child Neurology Societies, Siena, Italy, April 11–13, 1985.