Original contributionThe role of p53, p21WAF1/C1P1, and bcl-2 in radioresistant colorectal carcinoma
References (40)
- et al.
A genetic model for colorectal tumorigenesis
Cell
(1990) - et al.
WAFT, a potential mediator of p53 tumor suppression
Cell
(1993) - et al.
bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas
Hum Pathol
(1995) - et al.
High dose preoperative irradiation for cancer of the rectum
Int J Radiat Oncol Biol Phys
(1991) - et al.
Preoperative irradiation for tethered rectal carcinoma
Radiother Oncol
(1991) p53 Immunohistochemistry: A word of caution
Hum Pathol
(1994)- et al.
Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas
Hum Pathol
(1996) - et al.
Potential role of WAF1/C1P1/ p21 as a mediator of TGF-β cyto inhibitory effect
J Biol Chem
(1995) Cancer Facts and Figures—American Cancer Society, Cancer Facts & Figures
(1995)- et al.
Clinical implications of the p53 tumor-suppressor gene
N Engl J Med
(1993)
The tumor suppressor genes
Ann Rev Biochem
(1993)
Cell cycle control and cancer
Science
(1994)
Differential sensitivity of p53(−) and p53(+) cells to caffeine-induced radiosensitivity and override of G2 delay
Cancer Res
(1995)
Defective G2 checkpoint function in cells from individuals with familial cancer syndromes
Cancer Res
(1995)
Abrogation of the G2 checkpoint results in differential radiosensitivity of G1 checkpoint-deficient and G1 checkpoint-deficient competent cells
Cancer Res
(1995)
WAF1/C1PI is induced in p53 mediated G1 arrest and apoptosis
Cancer Res
(1994)
Analysis of the structure, transcripts and protein products of bcl-2, the gene involved in human follicular lymphoma
Wild-type p53 triggered apoptosis is inhibited by bcl-2 in v-myc induced T cell Lymphomas
Oncogene
(1993)
Differential expression of bcl-2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin
Cancer Res
(1991)
bcl-2 protein in non-small cell lung carcinoma
N Engl J Med
(1993)
Cited by (41)
Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse
2005, International Journal of Radiation Oncology Biology Physicsp53, bcl-2 and Ki-67 expression in adenoid cystic carcinoma of the palate. A clinico-pathologic study of 21 cases with long-term follow-up
2005, Pathology Research and PracticeColonic crypt changes during adenoma development in familial adenomatous polyposis: Immunohistochemical evidence for expansion of the crypt base cell population
2004, American Journal of PathologyCitation Excerpt :Like FAP adenomas, in the development of sporadic colon cancers, a mutation in the second APC allele usually occurs by the adenomatous polyp stage, and complete inactivation of wild-type APC occurs in the majority of colorectal carcinomas.48 In sporadic CRC6,7,9 as in our FAP adenomatous crypts, there was an increase in the proportion of total neoplastic epithelial cells staining for Bcl-2, survivin, and Ki-67 compared to normal colonic mucosa. Colon carcinomas are reported to contain fewer cells expressing p21WAF1/C1P1 and p27kip1 than normal epithelium,13,14,49 and we observed only a slight increase in the proportion of p21WAF1/C1P1- and p27kip1-stained cells in FAP adenomas.
Radiation-associated changes in tissues and tumours
2003, Current Diagnostic PathologyThe role of apoptosis-related genes in non-small-cell lung cancer
2002, Clinical Lung Cancerp53 expression in human rectal tissue after radiotherapy: Upregulation in normal mucosa versus functional loss in rectal carcinomas
2002, International Journal of Radiation Oncology Biology Physics
Copyright © 1997 Published by Elsevier Inc.