Focal white-matter lesions in brain of patients with inflammatory bowel disease
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2021, Journal of the Neurological SciencesAccuracy and reproducibility of automated white matter hyperintensities segmentation with lesion segmentation tool: A European multi-site 3T study
2021, Magnetic Resonance ImagingCitation Excerpt :White matter hyperintensities (WMHs) are a marker of white matter tissue damage seen as hyperintense signals on T2 and Fluid Attenuated Inversion Recovery (FLAIR) images. They are a potential hallmark of various disorders such as cerebrovascular disease [1], other neurological [2] (e.g. multiple sclerosis, MS, and dementia) [3,4], psychiatric [5] or inflammatory disorders [1,6]. Moreover, WMHs are commonly seen also in cognitively unimpaired people [7], and their prevalence increases with aging [8].
Persistent central inflammation and region specific cellular activation accompany depression- and anxiety-like behaviours during the resolution phase of experimental colitis
2019, Brain, Behavior, and ImmunityCitation Excerpt :There has been a recent surge of interest in the clinical literature regarding the effects of IBD on brain structure and function using neuroimaging tools. Originally, the focus was white matter lesions, visible in T2-weighted images, which were more prevalent in IBD patients compared to controls (Geissler et al., 1995; Hart et al., 1998; Chen et al., 2012). More recent studies have shown brain morphologic changes observed in patients with IBD, although some conflicting studies show no differences in brain structure between IBD patients and controls (Agostini et al., 2015), though these patients had a very mild clinical course of UC.