Research LettersHypertensive cardiovascular damage in patients with primary autonomic failure
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2022, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :The subsequent, progressive loss of renal function may thus derived from increased vascular resistance and BP lability including orthostatic hypotension, which may contribute to renal hypoperfusion and a decline in eGFR (Garland et al., 2009). Left-ventricular mass index (LVMI) in patients with both central and peripheral autonomic failure and in those with essential hypertension is similar and significantly higher than normotensive controls (Maule et al., 2006; Vagaonescu et al., 2000). Various mechanisms may be postulated, such as advanced age, blood pressure load, blood pressure variability, and myocite fibrotic damage induced by mineralocorticoids (Maule et al., 2006).
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2020, Autonomic Neuroscience: Basic and Clinical
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