Personality traits and striatal 6-[18F]fluoro-l-dopa uptake in healthy elderly subjects
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Acknowledgements
The present study was supported by the Päivikki and Sakari Sohlberg Foundation and Turku University Central Hospital (EVO). The authors thank the staff of the Turku PET Centre.
References (13)
- et al.
Regioselective radiofluorodestannylation with [18F]F2 and [18F]CH3COOF: a high yield synthesis of 6-[18F]fluoro-l-dopa
Int. J. Rad. Appl. Instrum.
(1992) - et al.
Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking
Neuroimage
(2001) - et al.
Relation among dopamine D2 receptor binding, obesity and personality in normal human subjects
Neurosci. Lett.
(2001) - et al.
Electrophilic synthesis of 6-[18F]fluoro-l-dopa, starting from aqueous [18F]-fluoride [abstract]
J. Label. Compounds Radiopharm.
(1994) - et al.
Dopamine D2 receptor density and personal detachment in healthy subjects
Am. J. Psychiatry
(1998) - et al.
A psychobiological model of temperament and character
Arch. Gen. Psychiatry
(1993)
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Anxiety and Harm Avoidance
2016, Neuroimaging Personality, Social Cognition, and CharacterDopamine D1 receptor availability is related to social behavior: A positron emission tomography study
2014, NeuroImageCitation Excerpt :In contrast, [11C]SCH23390 binding has not been affected by changes in endogenous DA levels in studies employing pharmacological challenges (Abi-Dargham et al., 1999; Chou et al., 1999; Verhoeff et al., 2001), suggesting that the present results are primarily driven by individual differences in the expression of post-synaptic D1-R. This focus on markers of the post-synaptic neuron is in line with findings of no association between pre-synaptic [18F]-DOPA uptake and social conformity (Kaasinen et al., 2002; Laakso et al., 2003; Stokes et al., 2013). In the interpersonal model of personality, the affiliation dimension spans from being affectionate, cooperative, and sympathetic to being cold and distant, and showing a threatening behavior, thus reflecting pro- and antisocial behaviors, respectively (Kiesler, 1983).
Neural correlates of personality: An integrative review
2013, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The neural correlates of personality have also been proposed to be an endophenotype for psychopathological disorders, which makes this line of research valuable for genetic studies as well (Gottesman and Gould, 2003; Bienvenu and Stein, 2003). Several studies have indeed found an association between genes involved in neurotransmission and personality dimensions (Passamonti et al., 2006; Buckholtz et al., 2008; Surguladze et al., 2008; Eley et al., 2003; Henderson et al., 2000; Kaasinen et al., 2002; Reuter et al., 2006; Stein et al., 2005). Thus, the neurobiological personality model that is presented in this review may provide a useful framework to link genetics of individual differences in personality to aspects of brain function as revealed by fMRI.
Serotonin-dependent depression in Parkinson's disease: A role for the subthalamic nucleus?
2011, NeuropharmacologyCitation Excerpt :Although there is little evidence that STN DBS alters global personality traits, a subset of patients show worsening or loss of planning, persistence, initiative and perseveration (Houeto et al., 2002). PD-related changes in dopamine metabolism have been associated with this personality trait (Kaasinen et al., 2001, 2002). However, Cloninger amongst others have linked harm avoidance to 5-HT mechanisms (Cloninger, 1987).
Functional imaging studies of non-motoric manifestations of Parkinson's Disease
2009, Parkinsonism and Related DisordersCitation Excerpt :This study has yet to be reproduced and would benefit from the availability of more selective ligands for the noradrenalin transporter. It is furthermore of interest that while this study would suggest that depression is likely to be associated with reduced dopamine innervation in the amygdala and ventral striatum, harm avoidance, a personality trait that is correlated with anxiety and depression, is positively correlated with fluorodopa uptake in the right caudate nucleus of PD patients [23] (but not in healthy controls [24]). Impulse control disorders affect a significant proportion of patients with PD, particularly those treated with dopamine agonists, and may manifest in several forms, including compulsive drug use, pathological gambling, hypersexuality, compulsive shopping and compulsive internet use.