Elsevier

Neuroscience Letters

Volume 251, Issue 3, 31 July 1998, Pages 205-208
Neuroscience Letters

Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

https://doi.org/10.1016/S0304-3940(98)00504-7Get rights and content

Abstract

α-Synuclein forms the major component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. Here we show that α-synuclein is also the major component of the filamentous inclusions of multiple system atrophy which comprises several neurodegenerative diseases with a shared filamentous pathology in nerve cells and glial cells. These findings provide an unexpected link between multiple system atrophy and Lewy body disorders and establish that α-synucleinopathies constitute a major class of human neurodegenerative disorder.

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Acknowledgements

We are grateful to Dr. S.E. Daniel (Parkinson's Disease Society Brain Bank) for providing some of the tissues used in this study. We thank C. Villa for assistance with photography.

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