Acute and transient increase of lipocalin-type prostaglandin D synthase (β-trace) level in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage
References (15)
- et al.
Prostaglandin D synthase concentration in cerebrospinal fluid and serum of patients with neurological disorders
Prostaglandins
(1997) - et al.
Lipocalin-type prostaglandin D synthase (β-trace) is a newly recognized type of retinoid transporter
J. Biol. Chem.
(1997) - et al.
Beta-trace protein concentration in cerebrospinal fluid is decreased in patients with bacterial meningitis
Neurosci. Lett.
(1998) - et al.
Prostaglandin D2 and sleep regulation
Biochim. Biophys. Acta
(1999) - et al.
Identification of beta-trace as prostaglandin D synthase
Biochem. Biophys. Res. Commun.
(1994) - et al.
Cisternal and lumbar CSF levels of arachidonate metabolites after subarachnoid haemorrhage: an assessment of the biochemical hypothesis of vasospasm
Acta Neurochir. (Wien)
(1987) - Beuckmann, C.T., Aoyagi, M., Okazaki, I., Hiroike, T., Toh, H., Hayaishi, O. and Urade, Y., Binding of biliverdin,...
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Neurobiological Basis of Hypersomnia
2017, Sleep Medicine ClinicsCitation Excerpt :These results suggest that the effect of LPS on sleep is partially dependent on PGs and is likely mediated mainly by other proinflammatory substances. On the other hand, the induction of L-PGDS or H-PGDS is observed in the brain of patients with various neurodegenerative diseases and their animal models, such as subarachnoid hemorrhage,80,81 demyelination,82–84 lysosomal storage disease,85 chronic multiple sclerosis,86 hypoxic ischemic injury,87,88 Alzheimer disease,89 and spinal cord contusion injury,90 the induction of which probably increases the PGD2 level in the brain91 and increases the production of various cytokines in the brain in a DP1 or DP2 receptor–dependent manner.82 Several natural compounds that induce NREM sleep after oral or IP administration to mice and rats have recently been identified, including hastatoside and verbenalin, which are iridoid compounds in the herbal tea Verbena92,93; ornithine94; crocin and crocetine from Crocus sativus L (saffron)95; glycine96; l-stepholidine,97 honokiol,98 and magnorol99 from Chinese herb and medicine; polyphenols from Korean seaweed100; methylthioadenosine from Japanese sake yeast101,102; Zn-containing yeast103,104; and triethylene glycol from the Indian medicine Ashwagandha (Fig. 8).105
Pharmacokinetics of recombinant human lipocalin-type prostaglandin D synthase/β-trace in canine
2008, Neuroscience ResearchPeroxisome-proliferator-activated receptor-gamma (PPARγ) activation protects neurons from NMDA excitotoxicity
2006, Brain ResearchCitation Excerpt :We are currently investigating this possibility. 15d-PGJ2 is a downstream product of prostaglandin D2, a prostaglandin uniquely enriched in brain along with its synthesizing enzyme (prostaglandin-D synthase), suggesting a high likelihood for involvement of 15d-PGJ2 in endogenous brain processes (Hayaishi, 2000; Mase et al., 1999). More recently, analysis of 552 patients with an acute stroke admitted within 24 h after symptom onset demonstrated that increased blood plasma 15d-PGJ2 concentration is associated with good early and late neurological outcome and smaller infarct volume (Blanco et al., 2005), suggesting an important role for 15d-PGJ2 in stroke pathogenesis.
Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of notch-HES signaling and enhancement of AP-2β function in brain-derived TE671 cells
2005, Journal of Biological ChemistryCitation Excerpt :Clinical studies showed the importance of many lipocalin gene family proteins including the L-PGDS (12). Actually, the L-PGDS level is enhanced in serum or cerebrospinal fluid of the patients with hypertension (57), arteriosclerosis (16), or subarachnoid hemorrhage (58). Thus, L-PGDS is thought to be useful as the diagnostic marker for those diseases (3, 4).