Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis
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Keywords
copper/zinc superoxide dismutase
transgenic mice
amyotrophic lateral sclerosis
nitric oxide
peroxynitrite
AR-R 17,477
Abbreviations
EDTA, ethylenediaminetetra-acetate
eNOS (NOS-3), endothelial nitric oxide synthase
FALS, familial amyotrophic lateral sclerosis
HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid
iNOS (NOS-2), immunological nitric oxide synthase
l-NAME, nitro-l-arginine methyl ester
MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
NADPH, reduced nicotinamide adenine dinucleotide phosphate
7-NI, 7-nitroindazole
nNOS (NOS-1), neuronal nitric oxide synthase
NO, nitric oxide
NOS, nitric oxide synthase
PCR, polymerase chain reaction
SOD-1, copper/zinc superoxide dismutase type 1
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Copyright © 1999 IBRO. Published by Elsevier Ltd. All rights reserved.