Effect of neuropeptides on cognitive function
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Functional neuroanatomy and disorders of cognition
2020, Cognitive Informatics, Computer Modelling, and Cognitive Science: Volume 2: Application to Neural Engineering, Robotics, and STEMTRH modulates glutamatergic synaptic inputs on CA1 neurons of the mouse hippocampus in a biphasic manner
2016, NeuropharmacologyCitation Excerpt :Collectively, these results suggest a TRH involvement in pathogenesis of depression. TRH also regulates cognitive functions (Bennett et al., 1997; Horita, 1998; Olson et al., 1995). TRH analogs are beneficial in animal models of amnesia and prevent the memory impairment caused by chronic ethanol administration and brain lesions (Ballard et al., 1996; Faden et al., 1999; Ogasawara et al., 1996; Sabbatini et al., 1998).
Neuroglialpharmacology: Myelination as a shared mechanism of action of psychotropic treatments
2012, NeuropharmacologyCitation Excerpt :Although TRH levels decrease in the hypothalamus in aging rats (Pekary et al., 1984), the levels seem to be preserved in healthy aging humans (Mazzoccoli et al., 2010) however, reduced levels are reported in AD (Luo et al., 2002). TRH can alter cognitive and emotional function (Bennett et al., 1997) and is prominently increased after electroconvulsive treatment (ECT), a widely used clinical intervention that is especially efficacious for severe melancholic and/or psychotic depression (Pekary et al., 1999) (reviewed in Sattin, 1999). ECT may also acutely inhibit GSK3 through the canonical mechanism of Akt activation (Kang et al., 2004; Roh et al., 2003) (Fig. 3).
Cognitive enhancers: Focus on modulatory signaling influencing memory consolidation
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :In some cases, these limitations are being circumvented by the development of intranasal formulations that allow efficient delivery of peptidergic molecules to the brain (Fehm et al., 2000). A general view of the role of neuropeptides in memory modulation has been presented in several reviews (Bennett et al., 1997; de Wied, 1997; Engelmann et al., 1996; Feany, 1996; Fehm et al., 2000; Gülpinar and Yegen, 2004; Huston and Hasenöhrl, 1995; Koob et al., 1989; Ogren et al., 2010). Here we will focus on the gastrin-releasing peptide (GRP) as an illustrative example of neuropeptide involved in modulating memory that can be targeted for cognitive enhancement.
Role of ethanolamine phosphate in the hippocampus of rats with acute experimental autoimmune encephalomyelitis
2011, Neurochemistry InternationalEmotion and episodic memory in neuropsychiatric disorders
2010, Behavioural Brain Research