Zonisamide and psychosis
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Cited by (28)
Epilepsy and psychosis
2024, Revue NeurologiqueInterictal psychosis of epilepsy
2020, EncephaleIncreased frequency of psychosis after second-generation antiepileptic drug administration in adults with focal epilepsy
2019, Epilepsy and BehaviorCitation Excerpt :While the frequency varies with each SAED (2.7–3.4%), each frequency is considerably higher. Reports on SAED-related psychoses have recently increased; e.g., vigabatrin (VGB) [26,27], ZNS [28], tiagabine (TGB) [29], LTG [30,31], TPM, [32,33], LEV [34,35], and GBP [36]. Whereas large controlled studies are limited, several comprehensive studies have reported a higher frequency of PAP with some SAED; ZNS [8,37], LEV [8], VGB [8], and TGB [8,10].
Pharmacotherapy in patients with epilepsy and psychosis
2018, Epilepsy and BehaviorCitation Excerpt :Some authors have strongly advocated that any potent AED can precipitate psychosis precisely because of the potent antiepileptic effects and that a subgroup of patients is particularly vulnerable to dramatic seizure reduction, irrespective of the AED used. In contrast, there are reports of psychotic symptoms specifically after exposure to certain AEDs [30–33] (including; ethosuximide [34], topiramate [35], felbamate [36], levetiracetam [37], zonisamide [38], vigabatrin [39], tiagabine [40], and lacosamide [41]). Whether they are specifically causal in the development of psychosis or not remains open to debate for reasons stated above.
Impact of antiepileptic drugs on genesis of psychosis
2012, Epilepsy and BehaviorCitation Excerpt :A line of case studies [23–27] has reported occurrence of frank psychosis in patients who received ZNS. Matsuura and Trimble [27] reported that the incidence of psychosis in patients treated with ZNS ranged from 1.9% to 2.3%, while the study of Miyamoto et al. [28] of 74 patients found that the incidence was much greater, ranging from 13% to 18%. According to the studies of White et al. [29] and Weintraub et al. [30], who used logistic regression analysis, ZNS possibly triggers various psychiatric symptoms, including depression, anxiety, and irritability, as well as psychosis.