Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter☆
Highlights
► Neurofilaments are phosphorylated ► Protein phosphorylation competes with the free proton binding capacity ► Magnetisation transfer depends on magnetisation exchange between macromolecular bound and free protons ► In multiple sclerosis the phosphorylation status of neurofilaments is changed in otherwise normal appearing axons ► In vivo assessment of early axonal pathology is possible using magnetisation transfer
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Financial support: KS has been supported by a Higher Education Funding Council for England (HEFCE) Clinical Senior Lectureship. Tissue for this study has been provided by the Multiple Sclerosis Tissue Bank (MSTB) based at Imperial College London. Part of this work was done at the NMR Research Unit of the UCL Institute of Neurology. The MSTB and the NMR Research Unit are supported by the MS Society of Great Britain and Northern Ireland. The NMR Research Unit is also supported by the UK Department of Health's NIHR Comprehensive Biomedical Research Centre at UCLH.