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Paraneoplastic Sensory Neuronopathy and Spontaneous Regression of Small Cell Lung Cancer

Published online by Cambridge University Press:  02 December 2014

Sharlene Gill
Affiliation:
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver BC
Nevin Murray
Affiliation:
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver BC
Josep Dalmau
Affiliation:
Canada and Department of Neurology, University of Arkansas for Medical, Sciences, Little Rock, Arkansas, USA
Brian Thiessen
Affiliation:
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver BC Division of Neurology, Vancouver General Hospital, Vancouver, BC
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Abstract

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Background:

Spontaneous tumour regression in small cell lung cancer has previously been suggested in patients with paraneoplastic neurologic syndromes. Rare documentation of this event has occurred in the literature.

Case Report:

The authors report a patient with anti-Hu associated paraneoplastic sensory neuronopathy who had a spontaneous regression of her small cell lung cancer.

Conclusions:

This case supports the hypothesis that anti-Hu neurologic syndromes are the consequence of a misdirected immune response to small cell tumours.

Résumé:

RÉSUMÉ:Introduction:

Une régression spontanée du cancer du poumon à petites cellules a déjà été observée chez des patients présentant des syndromes neurologiques paranéoplasiques. De rares cas ont été décrits dans la littérature.

Étude de cas:

Les auteurs rapportent le cas d’un patient présentant une neuropathie sensitive paranéoplasique avec anticorps anti-Hu chez qui un cancer du poumon à petites cellules a régressé spontanément.

Conclusions:

Ce cas appuie l’hypothèse selon laquelle les syndromes neurologiques anti-Hu sont la conséquence d’une réponse immunitaire aberrante à des tumeurs à petites cellules.

Type
Case Report
Copyright
Copyright © The Canadian Journal of Neurological 2003

References

1. Budde-Steffen, C, Anderson, NE, Rosenblum, MK, et al. Expression of an antigen in small cell lung carcinoma lines detected by antibodies from patients with paraneoplastic dorsal root gangliopathy. Cancer Res 1988;48:430434.Google Scholar
2. Graus, F, Dalmau, J, Rene, R et al. Anti-Hu antibodies in patients with small cell lung cancer - association with complete response to therapy and improved survival. J Clin Oncol 1997;15:28662872.Google Scholar
3. Darnell, RB, DeAngelis, LM. Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies. Lancet 1993;341:2122.Google Scholar
4. Keime-Guibert, F, Graus, F, Broet, P, et al. Clinical outcome of patients with anti-Hu associated encephalomyelitis after treatment of the tumour. Neurology 1999;53(8):17191723.Google Scholar
5. Smitt, PS, Grefkens, J, deLeeuw, B, et al. Survival and outcome in 73 anti-Hu positive patients with paraneoplastic encephalomyelitis/ sensory neuronopathy. J Neurol 2002; 249: 745753.Google Scholar
6. Furneaux, HM, Rosenblum, MK, Dalmau, J, et al. Selective expression of Purkinje-cell antigens in tumour tissue from patients with paraneoplastic cerebellar degeneration. N Engl J Med 1990;322:18441851.Google Scholar
7. Dalmau, J, Graus, F, Rosenblum, MK, et al. Anti-Hu associated paraneoplastic encephalomyelitis/sensory neuronopathy-a clinical study of 71 patients. Medicine (Baltimore) 1992;71:59.CrossRefGoogle ScholarPubMed