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Early vs. delayed radiotherapy in a small cohort of patients with supratentorial low grade glioma

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Abstract

In a cohort of 25 patients with supratentorial low grade glioma, the timing of radiotherapy made no significance difference for 10 year survival. Patients who received early radiotherapy had a 55% 10 year survival and those receiving delayed radiotherapy had a 53% 10 year survival. Radiotherapy was delayed a median of 4.8 years in those receiving delayed radiotherapy.

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References

  1. Fan KJ, Kovi J, Earle KM: The ethnic distribution of primary central nervous system tumors: AFIP, 1958 to 1970. J Neuropathol Exp Neurol 36(1): 41–49, 1977

    Google Scholar 

  2. Guthrie BL, Laws ER: Supratentorial low-grade gliomas. Neurosurgery Clinics of North America 1: 37–48

  3. Ammirati M, Vick N, Liao Y, Ciric I, Mikhael M: Effect of the extent of surgical resection on survival and quality of life in patients with supratentorial glioblastomas and anaplastic astrocytomas. Neurosurgery 21: 201–206, 1987

    Google Scholar 

  4. Ciric I, Ammirati M, Vick N, Mikhael M: Supratentorial gliomas: surgical considerations and immediate postoperative results. Gross total resection versus partial resection. Neurosurgery 21: 21–26, 1987

    Google Scholar 

  5. Fadul C, Wood J, Thaler H, Galicich J, Patterson RH, Posner JB: Morbidity and mortality of craniotomy for excision of supratentorial gliomas. Neurology 38: 1374–1379, 1988

    Google Scholar 

  6. Kristiansen K, Hagen S, Kollevold T, Torvik A, Holme I, Nesbakken R, Hatlevoll R, Lindgren M, Brun A, Lindgren S, Notter G, Andersen AP, Elgen K: Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group. Cancer 47(4): 649–652, 1981

    Google Scholar 

  7. Walker MD, Alexander E, Hunt WE, MacCarty CS, Mahaley MS, Mealey J, Norrell HA, Owens G, Ransohoff J, Wilson CB, Gehan EA, Strike TA: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg 49: 333–343, 1978

    Google Scholar 

  8. Walker MD, Green SB, Byar DP, Alexander E, Batzdorf U, Brooks WH, Hunt WE, MacCarty CS, Mahaley MS, Mealey J, Owens G, Ransohoff J, Robertson JT, Shapiro WR, Smith KR, Wilson CB, Strike TA: Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303: 1323–1329, 1980

    Google Scholar 

  9. Vecht CJ: Effect of age on treatment decisions in low-grade glioma. J Neurol Neurosurg Psychiatry 56: 1259–1264, 1993

    Google Scholar 

  10. Morantz RA: Low grade astrocytomas. In: Kaye AH, Laws ER (eds) Brain Tumors. Churchill Livingstone, Edinburgh, 433–448, 1995

    Google Scholar 

  11. Recht LD, Lew R, Smith TW: Suspected low-grade glioma: is deferring treatment safe? Ann Neurol 31: 431–436, 1992

    Google Scholar 

  12. Cairncross JG, Laperriere NJ: Low-grade glioma: to treat or not to treat? Arch Neuro 46: 1238–1239, 1989

    Google Scholar 

  13. Lunsford LD, Somaza S, Kondziolka D, Flickinger JC: Survival after stereotactic biopsy and irradiation of cerebral nonanaplastic, nonpilocytic astrocytoma. J Neurosurg 82: 523–529, 1995

    Google Scholar 

  14. Karim ABMF: Radiation therapy and radiosurgery for brain tumors. In: Kaye AH, Laws ER (eds) Brain Tumors. Churchill Livingstone, Edinburgh 331–348, 1995

    Google Scholar 

  15. Shaw EG, Daumas-Duport C, Scheithauer BW, Gilbertson DT, O'Fallon JR, Earle JD, Laws ER, Okazaki H: Radiation therapy in the management of low-grade supratentorial astrocytomas. J Neurosurg 70: 853–861, 1989

    Google Scholar 

  16. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457–481, 1958

    Google Scholar 

  17. Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50: 163–170, 1966

    Google Scholar 

  18. Al-Mefty O, Kersh JE, Routh A, Smith RR: The long-term side effects of radiation therapy for benign brain tumors in adults. J Neurosurg 73: 502–512, 1990

    Google Scholar 

  19. Sheline G, Wara W, Smith V: Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 6: 1215–1228, 1980

    Google Scholar 

  20. Leibel SA, Sheline GE: Radiation therapy for neoplasms of the brain. J Neurosurg 66: 1–22, 1987

    Google Scholar 

  21. Hoffman W, Levin V, Wilson C: Evaluation of malignant glioma patients during the postirradiation period. J Neurosurg 50: 624–628, 1979

    Google Scholar 

  22. Rottenberg D: Acute and chronic effects of radiation therapy on the nervous system. In: Neurological Complication of Cancer Treatment. Butterworth-Heineman, Boston 3–18, 1991

    Google Scholar 

  23. Sheline GE: Radiotherapy of adult primary cerebral neoplasms. In: Oncology of the Nervous System. Martinus Nijhoff, Boston 223–245, 1983

    Google Scholar 

  24. Armstrong C, Ruffer J, Corn B, DeVries K, Mollman J: Biphasic patterns of memory deficits following moderate-dose partial-brain irradiation: neuropsychologic outcome and proposed mechanisms. J Clin Oncol 13: 2263–2271, 1995

    Google Scholar 

  25. Janny P, Cure H, Mohr M, Heldt N, Kwiatkowski F, Lemaire J-J, Plagne R, Rozan R: Low grade supratentorial astrocytomas: management and prognostic factors. Cancer 73: 1937–1945, 1994

    Google Scholar 

  26. Soffietti R, Chio A, Giordana MT, Vasario E, Schiffer D: Prognostic factors in well-differentiated cerebral astrocytomas in the adult. Neurosurgery 24: 686–692, 1989

    Google Scholar 

  27. Vertosick F, Selker RG, Arena VC: Survival of patients with well-differentiated astrocytomas diagnosed in the era of computed tomography. Neurosurgery 28: 496–501, 1991

    Google Scholar 

  28. Steiger HJ, Markwalder RV, Seiler RW, Ebeling U, Reulen H-J: Early prognosis of supratentorial grade 2 astrocytomas in adult patients after resection or stereotactic biopsy. Acta Neurochir (Wien) 106: 99–105, 1990

    Google Scholar 

  29. North CA, North RB, Epstein JA, Piantadosi S, Wharam MD: Low-grade cerebral astrocytomas: survival and quality of life after radiation therapy. Cancer 66: 6–14, 1990

    Google Scholar 

  30. Cohadon F, Aouad N, Rougier A, Vital C, Rivel J, Dartigues JF: Histologic and non-histologic factors correlated with survival time in supratentorial astrocytic tumors. J Neuro-Oncology 3: 105–111, 1985

    Google Scholar 

  31. Philippon JH, Clemenceau SH, Fauchon FH, Foncin JF: Supratentorial low-grade astrocytomas in adults. Neurosurgery 32: 554–559, 1993

    Google Scholar 

  32. Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE, Shank B, Solin LJ, Wesson M: Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21: 109–122, 1991

    Google Scholar 

  33. Rubin P: The Franz Buschke Lecture: late effects of chemotherapy and radiation therapy: a new hypothesis. Int J Radiat Oncol Biol Phys 10: 5–34, 1984

    Google Scholar 

  34. Daumas-Duport C, Scheithauer B, Kelly P: A histologic and cytologic method for the spatial determination of gliomas. Mayo Clin Proc 62: 435–439, 1987

    Google Scholar 

  35. Kelly P, Daumas-Duport C, Scheithauer B, Kall B, Kispert D: Stereotactic histologic correlations of computed tomography and magnetic resonance imaging-defined abnormalities in patients with glial neoplasms. Mayo Clin Proc 62: 450–459, 1987

    Google Scholar 

  36. Dewit L, Van Der Scheuren E, Ang K, Van Den Bergh R, Dom R, Brucher J: Low grade astrocytoma in children treated by surgery and radiation therapy. Acta Radiol 23: 1–8, 1984

    Google Scholar 

  37. Pu AT, Sandler HM, Radany EH, Blavias M, Page MA, Greenberg HS, Junck L, Ross DA: Low grade gliomas: preliminary analysis of failure patterns among patients treated using 3D conformal external beam irradiation. Int J Radiat Oncol Biol Phys 31: 461–466, 1995

    Google Scholar 

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Knisely, J.P., Haffty, B.G. & Christopher, S.R. Early vs. delayed radiotherapy in a small cohort of patients with supratentorial low grade glioma. J Neurooncol 34, 23–29 (1997). https://doi.org/10.1023/A:1005703102687

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