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Comparative Analysis of Age-Related Changes in Activities of Monoamine Oxidase-B and Antioxidant Defense Enzymes in Various Structures of Human Brain

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Abstract

Activities of monoamine oxidase B, Cu-Zn-dependent superoxide dismutase (SOD), and catalase, and concentration of enzyme-active ceruloplasmin were measured in brain preparations from 43 humans died at the age of 21-92 years. Activity of monoamine oxidase B in the neocortex, cerebellum, basal ganglia, and stem structures increased with age, while SOD activity decreased and catalase and ceruloplasmin concentrations slightly increased. A contribution of age-related increase of cerebral monoamine oxidase activity into ontogenetic impairment of the antioxidant defense in human brain is discussed.

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Authors and Affiliations

  1. Department of General and Bioorganic Chemistry, Department of Normal Anatomy, Chelyabinsk State Medical Academy, Russia

    I. A. Volchegorskii, S. E. Shemyakov, V. V. Turygin & N. V. Malinovskaya

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  1. I. A. Volchegorskii
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  2. S. E. Shemyakov
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  3. V. V. Turygin
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  4. N. V. Malinovskaya
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Volchegorskii, I.A., Shemyakov, S.E., Turygin, V.V. et al. Comparative Analysis of Age-Related Changes in Activities of Monoamine Oxidase-B and Antioxidant Defense Enzymes in Various Structures of Human Brain. Bulletin of Experimental Biology and Medicine 132, 760–762 (2001). https://doi.org/10.1023/A:1013081912452

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