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A new brain region for coordinating speech articulation

Abstract

HUMAN speech requires complex planning and coordination of mouth and tongue movements. Certain types of brain injury can lead to a condition known as apraxia of speech, in which patients are impaired in their ability to coordinate speech movements but their ability to perceive speech sounds, including their own errors, is unaffected1,3. The brain regions involved in coordinating speech, however, remain largely unknown. In this study, brain lesions of 25 stroke patients with a disorder in the motor planning of articulatory movements were compared with lesions of 19 patients without such deficits. A robust double dissociation was found between these two groups. All patients with articulatory planning deficits had lesions that included a discrete region of the left precentral gyms of the insula, a cortical area beneath the frontal and temporal lobes. This area was completely spared in all patients without these articulation deficits. Thus this area seems to be specialized for the motor planning of speech.

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References

  1. Blumstein, S. in Acquired Aphasia 2nd edn (ed. Sarno, M. T.) 151–180 (Academic, San Diego 1991).

    Google Scholar 

  2. Johns, D. F. & Darley, F. L. J. Speech Hearing Res. 13, 556–583 (1970).

    Article  CAS  Google Scholar 

  3. Shankweiler, D. & Harris, K. S. Cortex 2, 277–292 (1966).

    Article  Google Scholar 

  4. Frey, R. T., Woods, D. L., Knight, R. T., Scabini, D. & Clayworth, C. Soc. Neurosci. Abstr. 13, 1266 (1987).

    Google Scholar 

  5. Talairach, J. & Tournoux, P. Co-planar Stereotaxic Atlas of the Human Brain (Thieme Medical, New York, 1988).

    Google Scholar 

  6. Marquardt, T. P. & Sussman, H. in Apraxia of Speech: Physiology, Acoustics, Linguistics, Management (eds Rosenbek, J. C., McNeil, M. R. & Aronson, A. E.) 91–112 (College-Hill, San Diego, 1984).

    Google Scholar 

  7. Square, P. A., Roy, E. A. & Martin, R. E. in Apraxia (eds Gonzalez-Rothi, L. & Heilman, K.) (Erlbaum, Hove, UK, in the press).

  8. Darley, F. L., Aronson, A. E. & Brown, J. R. Motor Speech Disorders (Saunders, Philadelphia, 1975).

    Google Scholar 

  9. Ruff, R. L. & Arbit, E. Neurology 31, 353–356 (1981).

    Article  CAS  Google Scholar 

  10. Schiff, H. B., Alexander, M. P., Naeser, M. A. & Galaburda, A. M. Arch. Neurol. 40, 720–727 (1983).

    Article  CAS  Google Scholar 

  11. Dronkers, N. F., Shapiro, J. K., Redfern, B. & Knight, R. T. J. Clin. Exp. Neuropsychol. 14, 52–53 (1992).

    Google Scholar 

  12. Luria, A. R. Higher Cortical Functions in Man (Basic Books, New York, 1966).

    Google Scholar 

  13. Kertesz, A. in Apraxia of Speech: Physiology, Acoustics, Linguistics, Management (eds Rosenbek, J. C., McNeil, M. R. & Aronson, A. E.) 73–90 (College–Hill, San Diego, 1984).

    Google Scholar 

  14. Tognola, G. R. & Vignolo, L. A. Neuropsychologia 18, 257–272 (1980).

    Article  CAS  Google Scholar 

  15. Halpern, H., Darley, F. L. & Brown, J. R. J. Speech Hearing Disord. 38, 162–173 (1973).

    Article  CAS  Google Scholar 

  16. Mesulam, M.-M. & Mufson, E. J. J. Comp. Neurol. 212, 1–22 (1982).

    Article  CAS  Google Scholar 

  17. Augustine, J. R. Neurol. Res. 7, 2–10 (1985).

    Article  CAS  Google Scholar 

  18. Schneider, R., Friedman, D. P. & Mishkin, M. Brain Res. 621, 116–120 (1993).

    Article  CAS  Google Scholar 

  19. Burton, H., Videen, T. O. & Raichle, M. E. Somatosens. Motor Res. 10, 297–308 (1993).

    Article  CAS  Google Scholar 

  20. Oppenheimer, S. M., Gelb, A., Girvin, J. P. & Hachinski, V. C. Neurology 42, 1727–1732 (1992).

    Article  CAS  Google Scholar 

  21. Ojemann, G. A. & Whitaker, H. A. Brain Language 6, 239–260 (1978).

    Article  CAS  Google Scholar 

  22. Habib, M. et al. Neuropsychologia 33, 327–339 (1995).

    Article  CAS  Google Scholar 

  23. Damasio, H. & Damasio, A. Brain 103, 337–350 (1980).

    Article  CAS  Google Scholar 

  24. Marie, P. Semaine Med. 26, 241–247 (1906).

    Google Scholar 

  25. Mazzocchi, F. & Vignolo, L. A. Cortex 15, 627–654 (1979).

    Article  CAS  Google Scholar 

  26. Vanier, M. & Caplan, D. in Agrammatic Aphasia: A Cross-linguistic Narrative Sourcebook (eds Menn, L & Obler, L.) 37–114 (Benjamins, Amsterdam, 1990).

    Google Scholar 

  27. Paulesu, E., Frith, C. D. & Frackowiak, R. S. J. Nature 362, 342–345 (1993).

    Article  ADS  CAS  Google Scholar 

  28. Wertz, R. T., Lapointe, L. L. & Rosenbek, J. C. Apraxia of Speech: The Disorder and its Management (Singular, San Diego, 1991).

    Google Scholar 

  29. DeArmond, S. J., Fusco, M. & Dewey, M. Structure of the Human Brain (Oxford Univ. Press, New York, 1976).

    Google Scholar 

Download references

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Dronkers, N. A new brain region for coordinating speech articulation. Nature 384, 159–161 (1996). https://doi.org/10.1038/384159a0

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