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The NOTCH4 locus is associated with susceptibility to schizophrenia

Abstract

Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A→G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

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Acknowledgements

We thank H. Hillman, R. Masters and I. Kilbourn for the collection of blood samples from family members; and A. Gliddon, P. Douglas, V. Hanson and L. Hughes for help.

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Correspondence to Jun Wei.

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Wei, J., Hemmings, G. The NOTCH4 locus is associated with susceptibility to schizophrenia . Nat Genet 25, 376–377 (2000). https://doi.org/10.1038/78044

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