Abstract
Although mutations in the β–amyloid precursor protein gene (APP) on chromosome 21 cause some cases of early–onset Alzheimer's disease (AD), most cases evidently do not have mutations in APP. We analysed ten early–onset families for linkage to APP and markers elsewhere in the genome. One family (F172) was consistent with linkage to chromosome 21 and was subsequently found to have an APP Val to lle mutation. Of the others, all but one were consistent with linkage to markers in the middle long arm of chromosome 14. However, no family showed independent evidence of linkage with two point analysis and only one showed independent evidence of linkage on multipoint analysis. Therefore, we cannot rule out heterogeneity at these loci although tests for heterogeneity were not significant.
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Mullan, M., Houlden, H., Windelspecht, M. et al. A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene. Nat Genet 2, 340–342 (1992). https://doi.org/10.1038/ng1292-340
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DOI: https://doi.org/10.1038/ng1292-340
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