Semin Neurol 2012; 32(01): 085-094
DOI: 10.1055/s-0032-1306391
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Leukoencephalopathies in Adulthood

Jan-Mendelt Tillema
1   Department of Neurology, Mayo Clinic, Rochester, Minnesota
,
Deborah L. Renaud
1   Department of Neurology, Mayo Clinic, Rochester, Minnesota
2   Department of Pediatrics, Mayo Clinic, Rochester, Minnesota
› Author Affiliations
Further Information

Publication History

Publication Date:
15 March 2012 (online)

Abstract

The understanding of the genetic basis of late-onset leukoencephalopathies has continued to increase in recent years. The most commonly presenting leukoencephalopathies in adulthood can be late-onset manifestations of metabolic pathways. The understanding of these diagnoses is crucial to the evaluation of adult patients presenting with leukoencephalopathies. The authors provide an overview of the common leukoencephalopathies in adulthood, the current understanding of the pathology, and genetics of these disorders with typical imaging findings. When available, treatment options will be discussed.

 
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