Chest
Clinical InvestigationsMaintenance of Wakefulness Test in Obstructive Sleep Apnea Syndrome
Section snippets
METHODS
A total of 322 consecutive obstructive sleep apnea patients were administered the MWT. We excluded from our series all patients who were in frank organ failure such as uncompensated congestive heart failure or chronic obstructive airways disease. Furthermore, we always attempted to evaluate patients after their systems were cleared of medications known to affect the central nervous system, in general, or sleep in particular. However, withdrawal of such drugs was not always possible due to the
RESULTS
Characteristics of the sleep apnea patients are shown in Table 1. Figure 1 shows the means and standard errors of the four MWT trials. The four-trial average MWT sleep latency was 26.0 min ±11.8 (SD).
Individual correlations between clinical data and MWT sleep latency are shown in Table 2. Note that respiratory events and subsequent arousals are the most highly correlated factors. Figure 2 shows the progressively lower MWT sleep latencies as the RAI increases. Many of the parameters, in
DISCUSSION
We have summarized our experiences with the MWT in obstructive sleep apnea. In clinically interpreting this test, mean sleep latencies above 33 appear to be normal in patients with no clinical sleep disorders. However, we have studied only a small number of control subjects at this time.9
The range of daytime alertness is quite broad at all levels of sleep apnea. We observed patients with normal MWTs whose RAI was in the 40 to 60 range, and some MWTs were markedly abnormal (less than 20 min) in
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2023, Encyclopedia of Sleep and Circadian Rhythms: Volume 1-6, Second EditionAutomatic identification of artifacts and unwanted physiologic signals in EEG and EOG during wakefulness
2017, Biomedical Signal Processing and ControlCitation Excerpt :Quantification of several types of EEG contamination may be important for evaluation of human subjects in different clinical conditions, and research studies. As an example, we can use this quantification to accompany routine Maintenance of Wakefulness Test (MWT) that is used clinically in disorders connected with excessive somnolence such as narcolepsy and sleep apnea syndrome [25,26]. MWT has also been used to examine treatment efficacy [26,27], by performing multiple tests and comparing results over a period of time, to determine if treatment is helping a patient to overcome sleepiness.
Obstructive sleep apnea syndrome and cognition: A review
2016, Neurophysiologie Clinique
Supported by PHS grants. R01 NS20459 and R03 AA08235 to Dr. Mitler, by Clinical Research Center grant RR00833 to Scripps Clinic and Research Foundation, by a grant from the American Narcolepsy Association, and by a grant from Seoul National University to Dr. Jeong (Teuk-jin-yeon-gu-bi, 1991). This is publication number 6549-NP from the Research Institute of Scripps Clinic.
Manuscript received May 17; revision accepted July 24.