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Management of Trigeminal Autonomic Cephalgias and Hemicrania Continua

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Abstract

The trigeminal autonomic cephalgias (TACs) are a group of primary headache disorders characterised by unilateral trigeminal distribution pain that occurs in association with ipsilateral cranial autonomic features. This group of headache disorders includes cluster headache, paroxysmal hemicrania and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT syndrome). Although hemicrania continua has previously been classified amongst the TACs, its nosological status remains unclear. Despite their similarities, these disorders differ in their clinical manifestations and response to therapy, thus underpinning the importance of recognising them. We have outlined the clinical manifestations, differential diagnoses, diagnostic workup and the treatment options for each of these syndromes.

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Acknowledgements

The work of the authors referred to herein was supported by the Wellcome Trust and the Migraine Trust. Peter J. Goadsby is a Wellcome Senior Research Fellow. The authors have no conflicts of interest that are directly relevant to the content of this manuscript.

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Matharu, M.S., Boes, C.J. & Goadsby, P.J. Management of Trigeminal Autonomic Cephalgias and Hemicrania Continua. Drugs 63, 1637–1677 (2003). https://doi.org/10.2165/00003495-200363160-00002

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