Cerebellar Form of Progressive Multifocal Leukoencephalopathy in a Patient with Chronic Renal Failure

Tatsuro IRIE; Masaharu KASAI; Nobuhiko ABE; Kazutoshi SETO; Tohru NAOHARA; Ken-ichi KAWAMURA; Toshio HIGA; Kimiaki SANO; Hidehiro TAKAHASHI; Kazuo NAGASHIMA

doi:10.2169/internalmedicine.31.218

Tatsuro IRIE, Masaharu KASAI, Nobuhiko ABE, Kazutoshi SETO, Tohru NAOHARA, Ken-ichi KAWAMURA, Toshio HIGA, Kimiaki SANO, Hidehiro TAKAHASHI, Kazuo NAGASHIMA

Author information

Tatsuro IRIE
Department of Internal Medicine, Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital
Masaharu KASAI
Department of Internal Medicine, Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital
Nobuhiko ABE
Department of Internal Medicine, Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital
Kazutoshi SETO
Department of Internal Medicine, Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital
Tohru NAOHARA
Department of Internal Medicine, Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital
Ken-ichi KAWAMURA
Department of Internal Medicine, Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital
Toshio HIGA
Department of Internal Medicine, Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital
Kimiaki SANO
Department of The Second Pathology, University of Hokkaido
Hidehiro TAKAHASHI
Department of The Second Pathology, University of Hokkaido
Kazuo NAGASHIMA
Department of The Second Pathology, University of Hokkaido

Keywords: progressive multifocal leukoencephalopathy, cerebellar symptom, chronic renal failure, impaired cell-mediated immunity, southern blotting of DNA

JOURNAL FREE ACCESS

1992 Volume 31 Issue 2 Pages 218-223

DOI https://doi.org/10.2169/internalmedicine.31.218

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Abstract

Progressive multifocal leukoencephalopathy (PML) developed in a 64-year-old woman who had undergone hemodialysis treatment due to chronic renal failure (CRF) for 6 yr. Her initial symptom was ataxia, and computed tomographic (CT) scan and magnetic resonance imaging (MRI) suggested a demyelinating disease of the cerebellum. Her cell-mediated immunity was impaired. At autopsy, the cerebellar disease was confirmed as PML by ultrastructual and immunohistochemical studies. Moreover, the JC type of papova virus infection was verified by Southern blot analysis.
(Internal Medicine 31 : 218-223, 1992)

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