Regular ArticlesAlzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits
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Supported by the Centre National de la Recherche Scientifique; the Fédération pour la Recherche sur le Cerveau; Gis-Longévité; the Institut National de la Santé et de la Recherche Médicale; the European Community (an integrated project for abnormal proteins in the pathogenesis of neurodegenerative diseases, LSHM-CT-2003-503330 and a Marie Curie Fellowship K.S.); the Association d'Etudes et de Recherche sur la Maladie d'Alzheimer; the International Alzheimer Research Foundation (to J.P.B.); and the Région Nord/Pas-de-Calais and Centre Hospitalier Régional Universitaire-Lille (scholarship to A.B.).
A.B. and K.L. contributed equally to this study.
Mice for this study were generated in collaboration with Günter Tremp and Nathalie Touchet from Sanofi-Aventis, Vitry-sur-Seine, France.
Supplemental material for this article can be found on http://ajp.amjpathol.org.