Abstract
Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.
MeSH terms
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Exons / genetics
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Family Health
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Female
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Genetic Predisposition to Disease
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Haplotypes
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Humans
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Linkage Disequilibrium
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Major Histocompatibility Complex / genetics
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Male
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Microsatellite Repeats
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Polymorphism, Single Nucleotide
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Promoter Regions, Genetic / genetics
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Proto-Oncogene Proteins / genetics*
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Receptor, Notch4
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Receptors, Cell Surface*
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Receptors, Notch
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Schizophrenia / genetics*
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Trinucleotide Repeats
Substances
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NOTCH4 protein, human
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Proto-Oncogene Proteins
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Receptor, Notch4
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Receptors, Cell Surface
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Receptors, Notch