Abstract
Akinesia is the most disabling symptom of Parkinson's disease. The neural mechanisms underlying it probably involve the descending projections of the basal ganglia to the brain stem as it improves after a pallidotomy or subthalamic nucleotomy but not after a thalamotomy. We describe the effects of lesioning the pedunculopontine nucleus in the normal primate in generating an akinetic syndrome. The possible clinical implications of this study are discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Animals
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Basal Ganglia / drug effects
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Basal Ganglia / pathology
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Basal Ganglia / physiopathology*
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Brain Mapping
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Brain Stem / drug effects
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Brain Stem / pathology
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Brain Stem / physiopathology*
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Dominance, Cerebral / drug effects
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Dominance, Cerebral / physiology
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Dyskinesia, Drug-Induced / pathology
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Dyskinesia, Drug-Induced / physiopathology*
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Female
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Macaca mulatta
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Neural Pathways / drug effects
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Neural Pathways / pathology
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Neural Pathways / physiopathology
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Parkinsonian Disorders / chemically induced
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Parkinsonian Disorders / pathology
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Parkinsonian Disorders / physiopathology*
Substances
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine