Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease

H R Siebner; C Rossmeier; C Mentschel; A Peinemann; B Conrad

doi:10.1016/s0022-510x(00)00370-1

Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease

J Neurol Sci. 2000 Sep 15;178(2):91-4. doi: 10.1016/s0022-510x(00)00370-1.

Authors

H R Siebner¹, C Rossmeier, C Mentschel, A Peinemann, B Conrad

Affiliation

¹ Department of Neurology, Technische Universität München, Moehlstrasse 28, D-81675, Munich, Germany. hartwig.siebner@neuro.medmtu-muenchen.de

PMID: 11018700
DOI: 10.1016/s0022-510x(00)00370-1

Abstract

Ten unmedicated patients with Parkinson's disease received sub-threshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area (M1(HAND)) contralaterally to the more affected upper limb. Compared to a midfrontal sham-rTMS, real-rTMS over M1(HAND) was associated with a significant decrease in the global motor UPDRS score 1 h after the cessation of rTMS. This was mainly due to a clinical improvement in the arm contralaterally to the stimulated M1(HAND). These preliminary data suggest that focal rTMS of M1(HAND) may have a therapeutic potential in PD.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Electromagnetic Fields*
Functional Laterality
Hand
Humans
Middle Aged
Motor Activity*
Parkinson Disease / physiopathology*
Parkinson Disease / therapy*
Transcranial Magnetic Stimulation / therapeutic use*