Abstract
We report a patient with MELAS treated for 24 months with idebenone and riboflavin, during which no stroke-like episodes occurred. Moreover neurological symptoms clearly improved, and a recovery of brain MRI and EEG abnormalities was observed. We conclude that the combined treatment with idebenone and riboflavin may restore the metabolic impairment in MELAS, possibly improving the long-term prognosis in these patients.
MeSH terms
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Adult
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Antioxidants / pharmacology*
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Aphasia, Wernicke / drug therapy
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Aphasia, Wernicke / etiology
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Aphasia, Wernicke / pathology
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Benzoquinones / pharmacology*
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Cerebral Cortex / pathology
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Cerebral Cortex / physiopathology
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Cerebral Infarction / drug therapy
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Cerebral Infarction / etiology
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Cerebral Infarction / pathology
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Drug Administration Schedule
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Drug Therapy, Combination
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Electron Transport / drug effects
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Electron Transport / genetics
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Humans
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MELAS Syndrome / complications
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MELAS Syndrome / drug therapy*
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MELAS Syndrome / physiopathology
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Magnetic Resonance Imaging
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Male
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Mitochondria / drug effects
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Mitochondria / genetics
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Mitochondria / metabolism
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Photosensitizing Agents / pharmacology*
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Riboflavin / pharmacology*
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Treatment Outcome
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Ubiquinone / analogs & derivatives
Substances
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Antioxidants
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Benzoquinones
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Photosensitizing Agents
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Ubiquinone
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idebenone
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Riboflavin